Seroatlas · Human Serome Atlas

TM9SF3

Transmembrane 9 superfamily member 3

Also known as: SMBP, TM9S3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD45
Gene
TM9SF3
Ensembl
ENSG00000077147
Chromosome
10
Canonical length
589 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be involved in protein localization to membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q9HD45|TM9SF3
     1  MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP YHNRQETYKY
    61  FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD DVMPATYCEI DLDKEKRDAF
   121  VYAIKNHYWY QMYIDDLPIW GIVGEADENG EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK
   181  VKLVPNTKIQ MSYSVKWKKS DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV
   241  SMILMRTLRK DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ
   301  IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ GGRRWIKQMF
   361  IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC ICFFVILPLN LVGTILGRNL
   421  SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV CLGGILPFGS IFIEMYFIFT SFWAYKIYYV
   481  YGFMMLVLVI LCIVTVCVTI VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK
   541  TKMYGLFQTS FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM9SF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
173 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 173 nTPM
  • duodenum: 110 nTPM
  • small intestine: 106 nTPM
  • colon: 105 nTPM
  • rectum: 89 nTPM
  • prostate: 86 nTPM

Single-cell type

  • mucous neck cells: 588 nCPM
  • prostatic glandular cells: 426 nCPM
  • parietal cells: 419 nCPM
  • gastric chief cells: 401 nCPM
  • gastric progenitor cells: 399 nCPM
  • goblet cells: 393 nCPM

Immune cell

  • plasmacytoid DC: 7.2 nTPM
  • basophil: 5.7 nTPM
  • MAIT T-cell: 4 nTPM
  • T-reg: 4 nTPM
  • memory CD8 T-cell: 3.9 nTPM
  • NK-cell: 3.9 nTPM

Brain region

  • white matter: 75 nTPM
  • spinal cord: 61 nTPM
  • choroid plexus: 60 nTPM
  • medulla oblongata: 60 nTPM
  • hypothalamus: 59 nTPM
  • cerebellum: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
3.51
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TM9SF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM9SF3 as an antibody target. Whether an autoantibody or antibody against TM9SF3 could matter depends on whether native TM9SF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM9SF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM9SF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TM9SF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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