Seroatlas · Human Serome Atlas

TRNP1

TMF-regulated nuclear protein 1

Also known as: C1orf225, TRNP, TRNP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NT89
Gene: TRNP1
Ensembl: ENSG00000253368
Chromosome: 1
Canonical length: 227 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in several processes, including cerebellar cortex morphogenesis; neural precursor cell proliferation; and regulation of cell population proliferation. Predicted to be located in euchromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q6NT89|TRNP1
     1  MPGCRISACG PGAQEGTAEQ RSPPPPWDPM PSSQPPPPTP TLTPTPTPGQ SPPLPDAAGA
    61  SAGAAEDQEL QRWRQGASGI AGLAGPGGGS GAAAGAGGRA LELAEARRRL LEVEGRRRLV
   121  SELESRVLQL HRVFLAAELR LAHRAESLSR LSGGVAQAEL YLAAHGSRLK KGPRRGRRGR
   181  PPALLASALG LGGCVPWGAG RLRRGHGPEP DSPFRRSPPR GPASPQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRNP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

stomach: 118 nTPM
esophagus: 81 nTPM
retina: 78 nTPM
cerebral cortex: 37 nTPM
heart muscle: 29 nTPM
cerebellum: 29 nTPM

Single-cell type

retinal bipolar cells: 374 nCPM
esophageal apical cells: 293 nCPM
foveolar cells: 112 nCPM
pancreatic duct cells: 98 nCPM
alveolar cells type 1: 79 nCPM
breast myoepithelial cells: 78 nCPM

Immune cell

intermediate monocyte: 0.6 nTPM
non-classical monocyte: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 89 nTPM
pons: 65 nTPM
thalamus: 63 nTPM
hypothalamus: 50 nTPM
medulla oblongata: 48 nTPM
cerebellum: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.38
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMF-regulated nuclear protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRNP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRNP1 as an antibody target. Whether an autoantibody or antibody against TRNP1 could matter depends on whether native TRNP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRNP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRNP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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