Seroatlas · Human Serome Atlas

TMEM132D

Transmembrane protein 132D

Also known as: KIAA1944, MOLT, PPP1R153, T132D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14C87
Gene: TMEM132D
Ensembl: ENSG00000151952
Chromosome: 12
Canonical length: 1099 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1099 residues, UniProt reviewed canonical sequence.

>Q14C87|TMEM132D
     1  MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF
    61  FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SIEQVVPQDL MLPSNPFGFT
   121  NKFSLNWKLK AHILRDKVYL SRPKVQVLFH IMGRDWDDRS AGEKLPCLRV FAFRETREVR
   181  GSCRLQGDLG LCVAELELLS SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV
   241  REDARRSNGI RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR
   301  KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD YTGKYAPAVI
   361  VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT WQVEYPGEIT SDLGVSKIYV
   421  SPKDLIGVVP LAMEAEILNT AILTGKTVAV PVKVVSVEDD GTVTELLESV ECRSSDEDVI
   481  KVSDRCDYVF VNGKEMKGKV NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG
   541  WRVPIVSSRR PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS
   601  DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI LAEKTITVLD
   661  EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL QRPKQEAAIS CWVQFSDGSV
   721  TPLDIYDGKD FSLMATSLDE KVVSIHQDPK FKWPIIAAET EGQGTLVKVE MVISESCQKS
   781  KRKSVLAVGT ANIKVKFGQN DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ
   841  YYGSSSMGLM EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE
   901  MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV PFEEQEGMSH
   961  SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES KYLLSTNSQK SINGQLFKPL
  1021  GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL
  1081  DPGDCKELHN YMERLHENV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM132D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.7 nTPM
basal ganglia: 3.2 nTPM
amygdala: 2.6 nTPM
hypothalamus: 2.4 nTPM
hippocampal formation: 1.7 nTPM
midbrain: 0.9 nTPM

Single-cell type

oligodendrocyte progenitor cells: 835 nCPM
pancreatic islet cells: 754 nCPM
brain inhibitory neurons: 359 nCPM
other brain neurons: 335 nCPM
brain excitatory neurons: 268 nCPM
pituitary stem cells: 246 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 26 nTPM
hypothalamus: 19 nTPM
basal ganglia: 18 nTPM
white matter: 17 nTPM
amygdala: 15 nTPM
hippocampal formation: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM132D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NCKAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM132D as an antibody target. Whether an autoantibody or antibody against TMEM132D could matter depends on whether native TMEM132D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM132D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM132D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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