TMEM132 fifth domain

Definition

This is the fifth domain of TMEM132 family of proteins which includes TMEM132A-E, transmembrane proteins that regulate neuronal structure and function. In mammalian cells, they may regulate NAP1 in the WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes. TMEM132D member has been associated with panic disorders, anxiety and major depressive disorders PMID:33726789. These proteins consist of six domains: N-terminal [pfam:PF15705], 2nd [pfam:PF23481], 3rd [pfam:PF23039], forth [pfam:PF16070], a fifth and a sixth one. The latter three are a tandem of Ig-like domains PMID:33726789. [pfam:PF15706] represents the C-terminal region which includes the single transmembrane helix.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• TMEM132A
• TMEM132B
• TMEM132C
• TMEM132D
• TMEM132E