TMEM132 N-terminal

Definition

This entry represents the N-terminal Ig-like domain found in TMEM132 family of proteins which includes TMEM132A-E, transmembrane proteins that regulate neuronal structure and function. In mammalian cells, they may regulate NAP1 in the WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes. TMEM132D member has been associated with panic disorders, anxiety and major depressive disorders [[cite:PMID:12966072],[cite:PMID:16806201],[cite:PMID:22948381],[cite:PMID:33726789]]. This entry represents five of the seven beta-sheets as the last two are contributed by more distant residues in the sequence (i.e residues 647-677 in TMEM132A).

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• TMEM132A
• TMEM132B
• TMEM132C
• TMEM132D
• TMEM132E