Seroatlas · Human Serome Atlas

LY6K

Lymphocyte antigen 6K

Also known as: CT97, FLJ35226, HSJ001348, LY6K_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q17RY6
Gene
LY6K
Ensembl
ENSG00000160886
Chromosome
8
Canonical length
165 aa
Protein class
Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Plasma membrane,Actin filaments,Acrosome,Equatorial segment,Mid piece
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in cell surface and plasma membrane. Predicted to be active in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q17RY6|LY6K
     1  MALLALLLVV ALPRVWTDAN LTARQRDPED SQRTDEGDNR VWCHVCEREN TFECQNPRRC
    61  KWTEPYCVIA AVKIFPRFFM VAKQCSAGCA AMERPKPEEK RFLLEEPMPF FYLKCCKIRY
   121  CNLEGPPINS SVFKEYAGSM GESCGGLWLA ILLLLASIAA GLSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • testis: 35 nTPM
  • esophagus: 12 nTPM
  • skin: 6.4 nTPM
  • vagina: 5.3 nTPM
  • adipose tissue: 5.1 nTPM
  • skeletal muscle: 5 nTPM

Single-cell type

  • early primary spermatocytes: 419 nCPM
  • esophageal apical cells: 278 nCPM
  • extravillous trophoblasts: 278 nCPM
  • breast myoepithelial cells: 84 nCPM
  • differentiating spermatogonia: 82 nCPM
  • esophageal suprabasal cells: 71 nCPM

Immune cell

  • neutrophil: 1.7 nTPM
  • basophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 7.7 nTPM
  • cerebral cortex: 7.2 nTPM
  • medulla oblongata: 6.2 nTPM
  • spinal cord: 6.2 nTPM
  • hypothalamus: 5.9 nTPM
  • white matter: 5.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LY6K.

Disease | ImmuneIEDB

Conditions an epitope on LY6K was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.01
gnomAD missense Z
0.48
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LY6K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6K as an antibody target. Whether an autoantibody or antibody against LY6K could matter depends on whether native LY6K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6K is annotated at the cell surface, where native LY6K is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6K. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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