Seroatlas · Human Serome Atlas

ADAM5

Putative disintegrin and metalloproteinase domain-containing protein 5

Also known as: ADAM5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NVV9
Gene: ADAM5
Canonical length: 412 aa

OverviewNCBI Gene

No narrative summary is available for ADAM5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q6NVV9|ADAM5
     1  MQTSILIKSS CRPQFQRRFH HRMQKQIQNI ISILSSASVI NSYDENDIRH SKPLLVQMDC
    61  NYNGYVAGIP NSLVTLSVCS GLRGTMQLKN ISYGIEPMEA VSGFIHKIYE EKYADTNILL
   121  EENDTYTWFN SEYQVRKSSE KTDFIKLFPR YIEMHIVVDK NLFKPANMIC RKSVGKECDF
   181  TEYCNGDLPY CLPDTYVRDG EYCDSGGAFC FQGKCRTFDK QCDDLIGRGS RGAPVFCYDE
   241  INTRGDNFGN CGTAHCLFQH ILCGKLVCTW EHRDLISRPN LSVIYAHVRD QTCVSTYLPR
   301  RTPPPVNSPI SITSYYSAED RDETFVQDGS MCGPDMYCFE MHCKHVRFLM NLKLCDASNH
   361  CDRHGVCNNF NHCHCEKGYN PPYCQPKQGA FGSIDDGHLV PPTERSYMEE GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

EGF-like domain

InteractionsUniProt · HPA

Protein binding partners of ADAM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TEX101

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAM5 as an antibody target. Whether an autoantibody or antibody against ADAM5 could matter depends on whether native ADAM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADAM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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