Seroatlas · Human Serome Atlas

STAG3

Cohesin subunit SA-3

Also known as: STAG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ98
Gene: STAG3
Ensembl: ENSG00000066923
Chromosome: 7
Canonical length: 1225 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

1225 residues, UniProt reviewed canonical sequence.

>Q9UJ98|STAG3
     1  MSSPLQRAVG DTKRALSASS SSSASLPFDD RDSNHTSEGN GDSLLADEDT DFEDSLNRNV
    61  KKRAAKRPPK TTPVAKHPKK GSRVVHRHSR KQSEPPANDL FNAVKAAKSD MQSLVDEWLD
   121  SYKQDQDAGF LELVNFFIQS CGCKGIVTPE MFKKMSNSEI IQHLTEQFNE DSGDYPLIAP
   181  GPSWKKFQGS FCEFVRTLVC QCQYSLLYDG FPMDDLISLL TGLSDSQVRA FRHTSTLAAM
   241  KLMTSLVKVA LQLSVHQDNN QRQYEAERNK GPGQRAPERL ESLLEKRKEL QEHQEEIEGM
   301  MNALFRGVFV HRYRDVLPEI RAICIEEIGC WMQSYSTSFL TDSYLKYIGW TLHDKHREVR
   361  LKCVKALKGL YGNRDLTTRL ELFTSRFKDR MVSMVMDREY DVAVEAVRLL ILILKNMEGV
   421  LTDADCESVY PVVYASHRGL ASAAGEFLYW KLFYPECEIR MMGGREQRQS PGAQRTFFQL
   481  LLSFFVESEL HDHAAYLVDS LWDCAGARLK DWEGLTSLLL EKDQNLGDVQ ESTLIEILVS
   541  SARQASEGHP PVGRVTGRKG LTSKERKTQA DDRVKLTEHL IPLLPQLLAK FSADAEKVTP
   601  LLQLLSCFDL HIYCTGRLEK HLELFLQQLQ EVVVKHAEPA VLEAGAHALY LLCNPEFTFF
   661  SRADFARSQL VDLLTDRFQQ ELEELLQSSF LDEDEVYNLA ATLKRLSAFY NTHDLTRWEL
   721  YEPCCQLLQK AVDTGEVPHQ VILPALTLVY FSILWTLTHI SKSDASQKQL SSLRDRMVAF
   781  CELCQSCLSD VDTEIQEQAF VLLSDLLLIF SPQMIVGGRD FLRPLVFFPE ATLQSELASF
   841  LMDHVFIQPG DLGSGDSQED HLQIERLHQR RRLLAGFCKL LLYGVLEMDA ASDVFKHYNK
   901  FYNDYGDIIK ETLTRARQID RSHCSRILLL SLKQLYTELL QEHGPQGLNE LPAFIEMRDL
   961  ARRFALSFGP QQLQNRDLVV MLHKEGIQFS LSELPPAGSS NQPPNLAFLE LLSEFSPRLF
  1021  HQDKQLLLSY LEKCLQHVSQ APGHPWGPVT TYCHSLSPVE NTAETSPQVL PSSKRRRVEG
  1081  PAKPNREDVS SSQEESLQLN SIPPTPTLTS TAVKSRQPLW GLKEMEEEDG SELDFAQGQP
  1141  VAGTERSRFL GPQYFQTPHN PSGPGLGNQL MRLSLMEEDE EEELEIQDES NEERQDTDMQ
  1201  ASSYSSTSER GLDLLDSTEL DIEDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

testis: 50 nTPM
bone marrow: 1 nTPM
heart muscle: 0.8 nTPM
thymus: 0.5 nTPM
esophagus: 0.4 nTPM
kidney: 0.4 nTPM

Single-cell type

oocytes: 1,340 nCPM
early primary spermatocytes: 230 nCPM
b-cells: 128 nCPM
myonuclei: 106 nCPM
epicardial cells: 84 nCPM
retinal horizontal cells: 72 nCPM

Immune cell

non-classical monocyte: 1.3 nTPM
plasmacytoid DC: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
classical monocyte: 0.7 nTPM
eosinophil: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM

Brain region

thalamus: 1.5 nTPM
cerebellum: 1.3 nTPM
cerebral cortex: 1.3 nTPM
white matter: 1.3 nTPM
medulla oblongata: 1.2 nTPM
basal ganglia: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAG3.

Disease | AllUniProt

Conditions STAG3 is implicated in, by any mechanism.

Premature ovarian failure 8 (POF8) MIM:615723
Spermatogenic failure 61 (SPGF61) MIM:619672

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 278 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 1.66
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAG3 as an antibody target. Whether an autoantibody or antibody against STAG3 could matter depends on whether native STAG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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