Seroatlas · Human Serome Atlas

TEKT3

Tektin-3

Also known as: FLJ32828, TEKT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXF9
Gene
TEKT3
Ensembl
ENSG00000125409
Chromosome
17
Canonical length
490 aa
Protein class
Predicted intracellular proteins
Subcellular location
Equatorial segment,Calyx,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q9BXF9|TEKT3
     1  MERVGCTLTT TYAHPRPTPT NFLPAISTMA SSYRDRFPHS NLTHSLSLPW RPSTYYKVAS
    61  NSPSVAPYCT RSQRVSENTM LPFVSNRTTF FTRYTPDDWY RSNLTNYQES NTSRHNSEKL
   121  RVDTSRLIQD KYQQTRKTQA DTTQNLGERV NDIGFWKSEI IHELDEMIGE TNALTDVKKR
   181  LERALMETEA PLQVARECLF HREKRMGIDL VHDEVEAQLL TEVDTILCCQ ERMKLHLDKA
   241  IAQLAANRAS QHELEKDLSD KQTAYRIDDK CHHLRNTSDG VGYFRGVERV DATVSVPESW
   301  AKFTDDNILR SQSERAASAK LRDDIENLLV VTANEMWNQF NKVNLSFTNR IAETADAKNK
   361  IQTHLAKTLQ EIFQTEMTIE SIKKAIKDKT AFLKVAQTRL DERTRRPNIE LCRDMAQLRL
   421  VNEVHEVDDT IQTLQQRLRD AEDTLQSLVH IKATLEYDLA VKANSLYIDQ EKCMSMRKSY
   481  PNTLRLVGFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • testis: 30 nTPM
  • fallopian tube: 4.6 nTPM
  • cerebellum: 2.4 nTPM
  • choroid plexus: 1.4 nTPM
  • basal ganglia: 1.1 nTPM
  • cervix: 1 nTPM

Single-cell type

  • late spermatids: 575 nCPM
  • early spermatids: 520 nCPM
  • late primary spermatocytes: 227 nCPM
  • respiratory ciliated cells: 80 nCPM
  • ependymal cells: 45 nCPM
  • endometrial ciliated cells: 43 nCPM

Immune cell

  • basophil: 1.7 nTPM
  • neutrophil: 0.7 nTPM
  • NK-cell: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 5 nTPM
  • white matter: 4.3 nTPM
  • medulla oblongata: 4.1 nTPM
  • midbrain: 4.1 nTPM
  • cerebral cortex: 3.6 nTPM
  • basal ganglia: 3.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TEKT3.

Disease | AllUniProt

Conditions TEKT3 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 81

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEKT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKT3 as an antibody target. Whether an autoantibody or antibody against TEKT3 could matter depends on whether native TEKT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKT3 is annotated at the cell surface, where native TEKT3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TEKT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TEKT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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