Seroatlas · Human Serome Atlas

TEKT5

Tektin-5

Also known as: CT149, FLJ32871, TEKT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M29
Gene: TEKT5
Ensembl: ENSG00000153060
Chromosome: 16
Canonical length: 485 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments

OverviewNCBI Gene

Predicted to be involved in cilium assembly and flagellated sperm motility. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q96M29|TEKT5
     1  MEFLGTTQTA SYCGPKKCCG LTSLPAVQAP VIQECYQPYY LPGYRYLNSW RPSLFYKIAN
    61  VQTCPDESTS TLRPPTILPT LRSALFSRYS PHDWDQSNQL QVRGAEASRL WASRLTDDSM
   121  RLLQDKDQLT HQMQEGTCRN LGQRLSDIGF WKSELSYELD RLLTENQNLE TVKRRLECAA
   181  NEVNCPLQVA LECLYHREKR IGIDLVHDNV EKNLIREVDL LKCCQEQMRK LAQRIDIQMR
   241  DNRDAQHVLE RDLEDKSSAQ CIDEKCFNLR NTSDCISFFH GMEKIDGTIS VPETWAKFSN
   301  DNIKHSQNMR ANSIQLREEA EHLFETLSDQ MWRQFTDTNL AFNARISEVT DVKNKLQTQL
   361  AKTLQEIFQA ENTIMLLERS IMAKEGPLKV AQTRLECRTR RPNMELCRDI PQLKLVNEVF
   421  TIDDTLQTLK LRLRETQDTL QLLVMTKCRL EHELAIKANT LCIDKEKCMG MRKTFPCTPR
   481  LVGHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEKT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
stomach: 0.9 nTPM
liver: 0.8 nTPM
urinary bladder: 0.5 nTPM
cerebral cortex: 0.4 nTPM
epididymis: 0.4 nTPM

Single-cell type

early spermatids: 772 nCPM
late spermatids: 238 nCPM
late primary spermatocytes: 67 nCPM
oocytes: 41 nCPM
undifferentiated spermatogonia: 12 nCPM
choroid plexus epithelial cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.8 nTPM
white matter: 1.2 nTPM
hippocampal formation: 1 nTPM
pons: 0.8 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -1.95
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEKT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TEKT3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEKT5 as an antibody target. Whether an autoantibody or antibody against TEKT5 could matter depends on whether native TEKT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEKT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEKT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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