Seroatlas · Human Serome Atlas

INA

Alpha-internexin

Also known as: AINX_HUMAN, NEF5, NF-66

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16352
Gene
INA
Ensembl
ENSG00000148798
Chromosome
10
Canonical length
499 aa
Protein class
Predicted intracellular proteins
Subcellular location
Intermediate filaments,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q16352|INA
     1  MSFGSEHYLC SSSSYRKVFG DGSRLSARLS GAGGAGGFRS QSLSRSNVAS SAACSSASSL
    61  GLGLAYRRPP ASDGLDLSQA AARTNEYKII RTNEKEQLQG LNDRFAVFIE KVHQLETQNR
   121  ALEAELAALR QRHAEPSRVG ELFQRELRDL RAQLEEASSA RSQALLERDG LAEEVQRLRA
   181  RCEEESRGRE GAERALKAQQ RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA
   241  TLQASSQAAA EVDVTVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR
   301  STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE VAGYQDSIGQ
   361  LENDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL EGEETRFSTS GLSISGLNPL
   421  PNPSYLLPPR ILSATTSKVS STGLSLKKEE EEEEASKVAS KKTSQIGESF EEILEETVIS
   481  TKKTEKSNIE ETTISSQKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 117 nTPM
  • hypothalamus: 99 nTPM
  • retina: 90 nTPM
  • cerebellum: 80 nTPM
  • midbrain: 63 nTPM
  • basal ganglia: 58 nTPM

Single-cell type

  • other brain neurons: 78 nCPM
  • pancreatic islet cells: 67 nCPM
  • corticotrophs: 61 nCPM
  • brain inhibitory neurons: 54 nCPM
  • cone photoreceptor cells: 52 nCPM
  • retinal bipolar cells: 49 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 385 nTPM
  • hypothalamus: 278 nTPM
  • pons: 263 nTPM
  • thalamus: 189 nTPM
  • medulla oblongata: 174 nTPM
  • cerebellum: 170 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on INA was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
2.13
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INA as an antibody target. Whether an autoantibody or antibody against INA could matter depends on whether native INA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INA is annotated as secreted, so native INA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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