TAFII28-like protein domain
IPR006809
Definition
The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. This entry represents a conserved domain found at the C terminus of Transcription initiation factor TFIID subunit 11 from humans (also known as Transcription initiation factor TFIID 28 kDa subunit, TAFII28 PMID:11963920). TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone PMID:10744685. It also interacts directly with TFIIA, acting as a bridging factor that stabilises the TFIIA-TBP-DNA complex PMID:15657423. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four α-helices and three loops arranged as in histone H3 [[cite:PMID:7729427], [cite:PMID:9695952]].
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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