Seroatlas · Human Serome Atlas

C1orf174

UPF0688 protein C1orf174

Also known as: CA174_HUMAN, RP13-531C17.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYL3
Gene: C1orf174
Ensembl: ENSG00000198912
Chromosome: 1
Canonical length: 243 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q8IYL3|C1orf174
     1  MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA TDTRTSKKFK
    61  CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS ALLPGSEAGV SVQQGAASLP
   121  LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD
   181  NSVFLDDDSN QPMPVSRFFG NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD
   241  AEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1orf174 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

liver: 17 nTPM
skeletal muscle: 14 nTPM
spleen: 13 nTPM
tongue: 13 nTPM
thymus: 13 nTPM
pancreas: 13 nTPM

Single-cell type

early spermatids: 163 nCPM
migrating cytotrophoblasts: 75 nCPM
extravillous trophoblasts: 74 nCPM
cytotrophoblasts: 68 nCPM
megakaryocytes: 56 nCPM
oocytes: 55 nCPM

Immune cell

basophil: 61 nTPM
eosinophil: 50 nTPM
intermediate monocyte: 50 nTPM
gdT-cell: 43 nTPM
MAIT T-cell: 38 nTPM
naive CD8 T-cell: 35 nTPM

Brain region

choroid plexus: 11 nTPM
spinal cord: 10 nTPM
cerebral cortex: 9.9 nTPM
white matter: 9.9 nTPM
pons: 9.7 nTPM
medulla oblongata: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

UPF0688 family
UPF0688 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1orf174 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1orf174 as an antibody target. Whether an autoantibody or antibody against C1orf174 could matter depends on whether native C1orf174 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1orf174 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C1orf174 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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