SSR3

Protein identityUniProt · HPA

UniProt accession

Q9UNL2

Gene

SSR3

Ensembl

ENSG00000114850

Chromosome

3

Canonical length

185 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q9UNL2|SSR3
     1  MAPKGSSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI WHMDLIQSAV
    61  LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV TRKLSEADNR KMSRKEKDER
   121  ILWKKNEVAD YEATTFSIFY NNTLFLVVVI VASFFILKNF NPTVNYILSI SASSGLIALL
   181  STGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

171 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SSR3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital disorder of glycosylation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.53

gnomAD pLI

0.75

gnomAD missense Z

0.77

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• SRP-dependent cotranslational protein targeting to membrane

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• Translocon-associated protein subunit gamma
• Translocon-associated protein, gamma subunit (TRAP-gamma)

KeywordsUniProt

• Acetylation
• Endoplasmic reticulum
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SSR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HECW1
• CANX
• DDOST
• RPL5
• RPN1