Seroatlas · Human Serome Atlas

SSBP2

Single-stranded DNA-binding protein 2

Also known as: HSPC116, SSBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P81877
Gene: SSBP2
Ensembl: ENSG00000145687
Chromosome: 5
Canonical length: 361 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>P81877|SSBP2
     1  MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK NITLGEPPGF
    61  LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP SPVLGNIPPG DGMPVGPVPP
   121  GFFQPFMSPR YPGGPRPPLR IPNQALGGVP GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP
   181  PRGMVPLGPQ NYGGAMRPPL NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY
   241  VGPPGGGGPP GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM
   301  ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS ESYSPSMTMS
   361  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

thymus: 90 nTPM
retina: 50 nTPM
parathyroid gland: 45 nTPM
blood vessel: 41 nTPM
ovary: 38 nTPM
cervix: 32 nTPM

Single-cell type

thymocytes: 2,186 nCPM
hematopoietic stem cells: 1,661 nCPM
pituicytes/fscs: 1,402 nCPM
innate lymphoid cells: 1,172 nCPM
choroid plexus epithelial cells: 1,048 nCPM
ependymal cells: 1,039 nCPM

Immune cell

NK-cell: 61 nTPM
eosinophil: 61 nTPM
basophil: 61 nTPM
naive B-cell: 34 nTPM
naive CD4 T-cell: 31 nTPM
non-classical monocyte: 30 nTPM

Brain region

cerebellum: 68 nTPM
hypothalamus: 66 nTPM
midbrain: 64 nTPM
medulla oblongata: 54 nTPM
basal ganglia: 50 nTPM
spinal cord: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 2.45
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

single-stranded DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSBP2 as an antibody target. Whether an autoantibody or antibody against SSBP2 could matter depends on whether native SSBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...