Seroatlas · Human Serome Atlas

LMO4

LIM domain transcription factor LMO4

Also known as: LMO4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61968
Gene: LMO4
Ensembl: ENSG00000143013
Chromosome: 1
Canonical length: 165 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody ring

OverviewNCBI Gene

This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P61968|LMO4
     1  MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI
    61  GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN
   121  RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 240 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 240 nTPM
hippocampal formation: 138 nTPM
amygdala: 88 nTPM
stomach: 86 nTPM
salivary gland: 82 nTPM
tonsil: 82 nTPM

Single-cell type

lacrimal acinar cells: 1,217 nCPM
extravillous trophoblasts: 458 nCPM
esophageal apical cells: 399 nCPM
respiratory ionocytes: 384 nCPM
respiratory basal cells: 383 nCPM
migrating cytotrophoblasts: 381 nCPM

Immune cell

basophil: 31 nTPM
NK-cell: 22 nTPM
eosinophil: 20 nTPM
neutrophil: 15 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 12 nTPM

Brain region

cerebral cortex: 129 nTPM
basal ganglia: 106 nTPM
hippocampal formation: 104 nTPM
white matter: 76 nTPM
hypothalamus: 39 nTPM
medulla oblongata: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.68
gnomAD missense Z: 2.1
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMO4 as an antibody target. Whether an autoantibody or antibody against LMO4 could matter depends on whether native LMO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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