ISL2

Protein identityUniProt · HPA

UniProt accession

Q96A47

Gene

ISL2

Ensembl

ENSG00000159556

Chromosome

15

Canonical length

359 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Rods & Rings

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q96A47|ISL2
     1  MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA ACLKCAECSQ
    61  YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD LVMRARDSVY HIECFRCSVC
   121  SRQLLPGDEF SLREHELLCR ADHGLLLERA AAGSPRSPGP LPGARGLHLP DAGSGRQPAL
   181  RPHVHKQTEK TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ
   241  NKRCKDKKKS ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP
   301  WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN SMVPSPVET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

3.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.67

gnomAD pLI

0.11

gnomAD missense Z

1.23

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axonogenesis
• negative regulation of neuron differentiation
• neuron development
• neuron fate specification
• peripheral nervous system neuron development
• positive regulation of transcription by RNA polymerase II
• retinal ganglion cell axon guidance
• spinal cord motor neuron cell fate specification
• visceral motor neuron differentiation

Molecular functions

• cis-regulatory region sequence-specific DNA binding
• DNA binding
• DNA-binding transcription factor activity, RNA polymerase II-specific
• metal ion binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Zinc finger, LIM-type
• Homedomain-like superfamily
• Homeobox, conserved site
• Insulin gene enhancer protein ISL-1/2-like
• Insulin gene enhancer protein ISL-1/2-like, LIM domain1
• Homeodomain
• LIM domain

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• LIM domain
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of ISL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LHX4
• POU4F2
• SSBP2