IL36RN

Protein identityUniProt · HPA

UniProt accession

Q9UBH0

Gene

IL36RN

Ensembl

ENSG00000136695

Chromosome

2

Canonical length

155 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q9UBH0|IL36RN
     1  MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG
    61  VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF
   121  LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL36RN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

60 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL36RN.

Disease | AllUniProt

Conditions IL36RN is implicated in, by any mechanism.

• Psoriasis 14, pustular (PSORS14) MIM:614204

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 213 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Generalized pustular psoriasis
• Acrodermatitis continua suppurativa of Hallopeau
• Autoinflammatory syndrome
• IL36RN-related disorder

ReferencesPubMed · IEDB

Publications for IL36RN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.9

gnomAD pLI

0

gnomAD missense Z

-0.43

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antifungal humoral response
• cellular response to lipopolysaccharide
• immune response
• inflammatory response
• innate immune response
• negative regulation of cytokine-mediated signaling pathway
• negative regulation of interleukin-17 production
• negative regulation of interleukin-6 production
• negative regulation of type II interferon production

Molecular functions

• cytokine activity
• interleukin-1 receptor antagonist activity
• interleukin-1 receptor binding

Cellular components

• cytoplasm
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Interleukin-1 family
• Interleukin-1 receptor antagonist/Interleukin-36
• Cytokine IL1/FGF
• Interleukin-1 conserved site
• Interleukin-1 / 18

KeywordsUniProt

• Cytokine
• Cytoplasm
• Disulfide bond
• Immunity
• Innate immunity
• Secreted

InteractionsUniProt · HPA

Protein binding partners of IL36RN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SSBP2