Seroatlas · Human Serome Atlas

SSBP4

Single-stranded DNA-binding protein 4

Also known as: SSBP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWG4
Gene: SSBP4
Ensembl: ENSG00000130511
Chromosome: 19
Canonical length: 385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q9BWG4|SSBP4
     1  MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN ITLGEPPGFL
    61  HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS PVMGSMAPGD TMAAGSMAAG
   121  FFQGPPGSQP SPHNPNAPMM GPHGQPFMSP RFPGGPRPTL RMPSQPPAGL PGSQPLLPGA
   181  MEPSPRAQGH PSMGGPMQRV TPPRGMASVG PQSYGGGMRP PPNSLAGPGL PAMNMGPGVR
   241  GPWASPSGNS IPYSSSSPGS YTGPPGGGGP PGTPIMPSPG DSTNSSENMY TIMNPIGQGA
   301  GRANFPLGPG PEGPMAAMSA MEPHHVNGSL GSGDMDGLPK SSPGAVAGLS NAPGTPRDDG
   361  EMAAAGTFLH PFPSESYSPG MTMSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 158 nTPM
pituitary gland: 126 nTPM
amygdala: 115 nTPM
hippocampal formation: 110 nTPM
cerebral cortex: 105 nTPM
fallopian tube: 89 nTPM

Single-cell type

fallopian tube ciliated cells: 280 nCPM
respiratory ciliated cells: 265 nCPM
ependymal cells: 192 nCPM
epididymal efferent duct ciliated cells: 178 nCPM
pancreatic islet cells: 117 nCPM
endometrial ciliated cells: 114 nCPM

Immune cell

non-classical monocyte: 26 nTPM
intermediate monocyte: 15 nTPM
memory B-cell: 15 nTPM
gdT-cell: 12 nTPM
naive B-cell: 11 nTPM
memory CD8 T-cell: 10 nTPM

Brain region

choroid plexus: 186 nTPM
basal ganglia: 181 nTPM
hippocampal formation: 164 nTPM
amygdala: 155 nTPM
cerebral cortex: 148 nTPM
hypothalamus: 143 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.37
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSBP4 as an antibody target. Whether an autoantibody or antibody against SSBP4 could matter depends on whether native SSBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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