SRMS

Protein identityUniProt · HPA

UniProt accession

Q9H3Y6

Gene

SRMS

Ensembl

ENSG00000125508

Chromosome

20

Canonical length

488 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Intermediate filaments,Actin filaments,Cytosol

OverviewNCBI Gene

Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine autophosphorylation and positive regulation of TORC1 signaling. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9H3Y6|SRMS
     1  MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS PFPQLFLALY
    61  DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG LVPITHVAKA SPETLSDQPW
   121  YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE SSLGGYSLSV RAQAKVCHYR VSMAADGSLY
   181  LQKGRLFPGL EELLTYYKAN WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY
   241  FGEVWEGLWL GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI
   301  VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD LAARNVLVDD
   361  GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY RVFSQKSDVW SFGVLLHEVF
   421  TYGQCPYEGM TNHETLQQIM RGYRLPRPAA CPAEVYVLML ECWRSSPEER PSFATLREKL
   481  HAIHRCHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRMS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

2.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.52

gnomAD pLI

0

gnomAD missense Z

0.01

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• cell surface receptor protein tyrosine kinase signaling pathway
• negative regulation of signal transduction
• peptidyl-tyrosine autophosphorylation
• peptidyl-tyrosine phosphorylation
• positive regulation of TORC1 signaling

Molecular functions

• ATP binding
• non-membrane spanning protein tyrosine kinase activity
• protein tyrosine kinase activity
• signaling receptor binding

Cellular components

• cytoplasm
• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• SH2 domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• SH3 domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• SH3-like domain superfamily
• SH2 domain superfamily
• Non-receptor tyrosine kinases involved in cell signaling
• SH2 domain
• Protein tyrosine and serine/threonine kinase

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Phosphoprotein
• SH2 domain
• SH3 domain
• Transferase
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of SRMS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• VIM
• DOK1
• CDC37
• FKBP5
• HSP90AB1