Seroatlas · Human Serome Atlas

C19orf84

piRNA-mediated silencing protein C19orf84

Also known as: CS084_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: I3L1E1
Gene: C19orf84
Ensembl: ENSG00000262874
Chromosome: 19
Canonical length: 186 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in transposable element silencing by piRNA-mediated DNA methylation. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>I3L1E1|C19orf84
     1  MEQPKDGAGP EGNNLSLPSS GTEPWPPAPL PAPPPLLLNS TDPTHLGLPE SVASVTVPIR
    61  LDTLSCLLHS ALLGAYTFQQ ALPSCPCCSQ AGHSQPGAVR RPPRGRGGWE VRHRPGWGRG
   121  LHRRGLGRAE QPERGRAGGP GAGPRTPPMT LPSPPTLPAQ DGKKEARGPE PPLETPLAAE
   181  DWETEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C19orf84 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
bone marrow: 0.6 nTPM
spleen: 0.3 nTPM
appendix: 0.2 nTPM
basal ganglia: 0.2 nTPM
lymph node: 0.2 nTPM

Single-cell type

undifferentiated spermatogonia: 53 nCPM
differentiating spermatogonia: 4.3 nCPM
nk-cells: 4.2 nCPM
late spermatids: 3.2 nCPM
epididymal efferent duct absorptive cells: 3.1 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM

Immune cell

gdT-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 0.6 nTPM
thalamus: 0.6 nTPM
cerebellum: 0.5 nTPM
medulla oblongata: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.35
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.07
DepMap dependency class: selective

OntologyGO

Biological processes

transposable element silencing by piRNA-mediated DNA methylation

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

piRNA-mediated silencing protein C19orf84
piRNA-mediated silencing protein C19orf84

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of C19orf84 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPOCD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C19orf84 as an antibody target. Whether an autoantibody or antibody against C19orf84 could matter depends on whether native C19orf84 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C19orf84 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C19orf84 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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