SPINK7
Serine protease inhibitor Kazal-type 7
Also known as: ECG2, ECRG2, ISK7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P58062
- Gene
- SPINK7
- Ensembl
- ENSG00000145879
- Chromosome
- 5
- Canonical length
- 85 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
85 residues, UniProt reviewed canonical sequence.
>P58062|SPINK7
1 MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL PVCGSDYITY
61 GNECHLCTES LKSNGRVQFL HDGSCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPINK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 628 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 628 nTPM
- vagina: 602 nTPM
- cervix: 517 nTPM
- salivary gland: 122 nTPM
- tonsil: 109 nTPM
- skin: 10 nTPM
Single-cell type
- esophageal apical cells: 24,075 nCPM
- suprabasal keratinocytes: 163 nCPM
- esophageal suprabasal cells: 73 nCPM
- ocular epithelial cells: 27 nCPM
- esophageal basal cells: 21 nCPM
- epididymal clear cells: 20 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.6 nTPM
- cerebral cortex: 0.6 nTPM
- pons: 0.6 nTPM
- midbrain: 0.5 nTPM
- thalamus: 0.5 nTPM
- white matter: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.42
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -0.04
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPINK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPINK7 as an antibody target. Whether an autoantibody or antibody against SPINK7 could matter depends on whether native SPINK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPINK7 is annotated as secreted, so native SPINK7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPINK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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