Seroatlas · Human Serome Atlas

MT1H

Metallothionein-1H

Also known as: MT1, MT1H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80294
Gene: MT1H
Ensembl: ENSG00000205358
Chromosome: 16
Canonical length: 61 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P80294|MT1H
     1  MDPNCSCEAG GSCACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIC KGASEKCSCC
    61  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 1,081 nTPM

Expression across tissuesHPA

Tissue

liver: 1,081 nTPM
kidney: 853 nTPM
thyroid gland: 304 nTPM
small intestine: 280 nTPM
pancreas: 193 nTPM
colon: 111 nTPM

Single-cell type

endometrial luminal cells: 3,834 nCPM
hepatocytes: 3,263 nCPM
enterocytes: 2,949 nCPM
gastric chief cells: 1,372 nCPM
epididymal efferent duct absorptive cells: 1,325 nCPM
pancreatic acinar cells: 968 nCPM

Immune cell

intermediate monocyte: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

basal ganglia: 35 nTPM
medulla oblongata: 24 nTPM
cerebral cortex: 18 nTPM
midbrain: 18 nTPM
pons: 14 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.01
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MT1H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPINK7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1H as an antibody target. Whether an autoantibody or antibody against MT1H could matter depends on whether native MT1H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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