Seroatlas · Human Serome Atlas

MT1G

Metallothionein-1G

Also known as: MT1, MT1G_HUMAN, MT1K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P13640
Gene: MT1G
Ensembl: ENSG00000125144
Chromosome: 16
Canonical length: 62 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

Enables zinc ion binding activity. Involved in several processes, including cellular response to cadmium ion; cellular response to copper ion; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

62 residues, UniProt reviewed canonical sequence.

>P13640|MT1G
     1  MDPNCSCAAA GVSCTCASSC KCKECKCTSC KKSCCSCCPV GCAKCAQGCI CKGASEKCSC
    61  CA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6,501 nTPM

Expression across tissuesHPA

Tissue

liver: 6,501 nTPM
kidney: 3,504 nTPM
thyroid gland: 2,685 nTPM
pancreas: 1,685 nTPM
stomach: 1,166 nTPM
small intestine: 1,019 nTPM

Single-cell type

gastric chief cells: 24,750 nCPM
hepatocytes: 16,899 nCPM
endometrial luminal cells: 16,037 nCPM
parietal cells: 9,513 nCPM
enterocytes: 7,694 nCPM
epididymal efferent duct absorptive cells: 7,260 nCPM

Immune cell

naive CD8 T-cell: 0.7 nTPM
T-reg: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
total PBMC: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM

Brain region

basal ganglia: 263 nTPM
medulla oblongata: 220 nTPM
midbrain: 185 nTPM
cerebellum: 170 nTPM
thalamus: 168 nTPM
pons: 165 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.03
gnomAD missense Z: -0.8
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MT1G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPINK7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT1G as an antibody target. Whether an autoantibody or antibody against MT1G could matter depends on whether native MT1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT1G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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