NIDO domain
IPR003886
Definition
The ~180-residue NIDO domain is an extracellular domain of unknown function, found in nidogen (entactin) and hypothetical proteins. The NIDO domain is found in association with other domains, such as nidogen G2 β-barrel ([interpro:IPR006605]), thyroglobulin type-1 ([interpro:IPR000716]), LDLRB ([interpro:IPR000033]), AMOP ([interpro:IPR005533]), EGF-like ([interpro:IPR000742]), VWFD, IPT/TIG, or sushi/CCP/SCR ([interpro:IPR000436]) [[cite:PMID:11893501], [cite:PMID:12084055], [cite:PMID:15053982], [cite:PMID:16500040]]. Some proteins known to contain a NIDO domain are listed below: Vertebrate nidogen-1 (NID-1) or entactin, a sulphated glycoprotein widely distributed in basement membranes. Vertebrate nidogen-2 (NID-2) or osteonidogen, a cell adhesion glycoprotein which is widely distributed in basement membranes. Vertebrate alpha-tectorin. Mammalian mucin-4 (MUC4), a highly glycosylated membrane-bound protein. Xenopus ID14, a putative matrix protein.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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