Seroatlas · Human Serome Atlas

SLFN12L

Schlafen family member 12-like

Also known as: SN12L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IEE8
Gene: SLFN12L
Canonical length: 588 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SLFN12L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q6IEE8|SLFN12L
     1  MDLARKEFLR GNGLAAGKMN ISIDLDTNYA ELVLNVGRVT LGENNRKKMK DCQLRKQQNE
    61  NVSRAVCALL NSGGGVIKAE VENKGYSYKK DGIGLDLENS FSNMLPFVPN FLDFMQNGNY
   121  FHIFVKSWSL ETSGPQIATL SSSLYKRDVT SAKVMNASAA LEFLKDMEKT GGRAYLRPEF
   181  PAKRACVDVQ EESNMEALAA DFFNRTELGY KEKLTFTEST HVEIKNFSTE KLLQRITEIL
   241  PQYVSAFANT DGGYLFVGLN EDKEVIGFKA EKSYLTKLEE VTKNSIGKLP VHHFCVEKGT
   301  INYLCKFLGV YDKGRLCGYV YALRVERFCC AVFAKKPDSW HVKDNRVKQL TEKEWIQFMV
   361  DSEPVCEELP SPASTSSPVS QSYPLREYIN FKIQPLRYHL PGLSEKITCA PKTFCRNLFS
   421  QHEGLKQLIC EEMGSVNKGS LIFSRSWSLD LGLQENHKVL CDALLISQDK PPVLYTFHMV
   481  QDEEFKDYST QTAQTLKQKL AKIGGYTKKV CVMTKIFYLS PEGKTSCQYD LNSQVIYPES
   541  YYWTTAQTMK DLEKALSNIL PKENQIFLFV CLFRFCLFVC WFVCFFLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLFN12L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

spleen: 4.4 nTPM
lymph node: 4 nTPM
bone marrow: 3.5 nTPM
appendix: 3 nTPM
salivary gland: 2.4 nTPM
tonsil: 2.4 nTPM

Single-cell type

nk-cells: 326 nCPM
t-cells: 270 nCPM
innate lymphoid cells: 64 nCPM
neutrophil progenitors: 26 nCPM
neutrophils: 22 nCPM
vascular endothelial cells: 14 nCPM

Immune cell

NK-cell: 2.1 nTPM
gdT-cell: 1.6 nTPM
memory CD8 T-cell: 1.2 nTPM
MAIT T-cell: 1 nTPM
memory CD4 T-cell: 1 nTPM
naive CD8 T-cell: 0.9 nTPM

Brain region

cerebellum: 24 nTPM
white matter: 23 nTPM
cerebral cortex: 23 nTPM
basal ganglia: 20 nTPM
amygdala: 19 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA catabolic process

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLFN12L as an antibody target. Whether an autoantibody or antibody against SLFN12L could matter depends on whether native SLFN12L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLFN12L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLFN12L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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