Seroatlas · Human Serome Atlas

SLC39A10

Zinc transporter ZIP10

Also known as: DKFZp564L2123, FLJ90515, KIAA1265, S39AA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULF5
Gene
SLC39A10
Ensembl
ENSG00000196950
Chromosome
2
Canonical length
831 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

831 residues, UniProt reviewed canonical sequence.

>Q9ULF5|SLC39A10
     1  MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK FSKQAAENEK
    61  KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN HEDLGHDHVS HLDILAVQEG
   121  KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN HKCDPEKETV EVSVKSDDKH MHDHNHRLRH
   181  HHRLHHHLDH NNTHHFHNDS ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS
   241  NENSEVITPG FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD
   301  NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG ANSPISTDLF
   361  TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA NIGASAWICG IISITVISLL
   421  SLLGVILVPI INQGCFKFLL TFLVALAVGT MSGDALLHLL PHSQGGHDHS HQHAHGHGHS
   481  HGHESNKFLE EYDAVLKGLV ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST
   541  IGRKLSDHKL NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE
   601  EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH SHGPCHSGSD
   661  LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI STSIAVFCHE LPHELGDFAV
   721  LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT AVGQYANNIT LWIFAVTAGM FLYVALVDML
   781  PEMLHGDGDN EEHGFCPVGQ FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 45 nTPM
  • cerebral cortex: 44 nTPM
  • prostate: 18 nTPM
  • spleen: 17 nTPM
  • placenta: 12 nTPM
  • endometrium: 10 nTPM

Single-cell type

  • microglia: 206 nCPM
  • prostatic glandular cells: 188 nCPM
  • vascular endothelial cells: 174 nCPM
  • ependymal cells: 159 nCPM
  • brain excitatory neurons: 144 nCPM
  • b-cells: 138 nCPM

Immune cell

  • basophil: 42 nTPM
  • plasmacytoid DC: 33 nTPM
  • NK-cell: 22 nTPM
  • naive B-cell: 16 nTPM
  • memory B-cell: 12 nTPM
  • naive CD8 T-cell: 7.8 nTPM

Brain region

  • cerebral cortex: 112 nTPM
  • basal ganglia: 84 nTPM
  • white matter: 82 nTPM
  • thalamus: 81 nTPM
  • amygdala: 80 nTPM
  • hippocampal formation: 71 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A10.

Disease | ImmuneIEDB

Conditions an epitope on SLC39A10 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
1.95
DepMap mean gene effect
-0.45
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC39A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A10 as an antibody target. Whether an autoantibody or antibody against SLC39A10 could matter depends on whether native SLC39A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A10 is annotated at the cell surface, where native SLC39A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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