ST3GAL1

Protein identityUniProt · HPA

UniProt accession

Q11201

Gene

ST3GAL1

Ensembl

ENSG00000008513

Chromosome

8

Canonical length

340 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q11201|ST3GAL1
     1  MVTLRKRTLK VLTFLVLFIF LTSFFLNYSH TMVATTWFPK QMVLELSENL KRLIKHRPCT
    61  CTHCIGQRKL SAWFDERFNQ TMQPLLTAQN ALLEDDTYRW WLRLQREKKP NNLNDTIKEL
   121  FRVVPGNVDP MLEKRSVGCR RCAVVGNSGN LRESSYGPEI DSHDFVLRMN KAPTAGFEAD
   181  VGTKTTHHLV YPESFRELGD NVSMILVPFK TIDLEWVVSA ITTGTISHTY IPVPAKIRVK
   241  QDKILIYHPA FIKYVFDNWL QGHGRYPSTG ILSVIFSMHV CDEVDLYGFG ADSKGNWHHY
   301  WENNPSAGAF RKTGVHDADF ESNVTATLAS INKIRIFKGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST3GAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

63 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0.58

gnomAD missense Z

1.3

DepMap mean gene effect

-0.24

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ganglioside biosynthetic process
• keratan sulfate proteoglycan biosynthetic process
• N-acetylneuraminate metabolic process
• negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
• protein modification process
• protein N-linked glycosylation
• protein O-linked glycosylation via N-acetyl-galactosamine
• protein sialylation
• sialylation
• viral protein processing
• memory B cell differentiation

Molecular functions

• beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase
• beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
• sialyltransferase activity

Cellular components

• extracellular exosome
• Golgi apparatus
• Golgi membrane
• membrane
• trans-Golgi network membrane
• Golgi medial cisterna membrane
• Golgi trans cisterna membrane

Protein domainsUniProt · Pfam · InterPro

• Glycosyl transferase family 29
• Sialyltransferase
• GT29-like superfamiliy
• Beta-galactoside alpha2-3 sialyltransferases
• Glycosyltransferase family 29 (sialyltransferase)

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Glycosyltransferase
• Golgi apparatus
• Lipid metabolism
• Membrane
• Secreted
• Signal-anchor
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ST3GAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SLC39A10