Seroatlas · Human Serome Atlas

IGDCC4

Immunoglobulin superfamily DCC subclass member 4

Also known as: IGDC4_HUMAN, LOC57722, NOPE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDY8
Gene: IGDCC4
Ensembl: ENSG00000103742
Chromosome: 15
Canonical length: 1250 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell-cell adhesion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1250 residues, UniProt reviewed canonical sequence.

>Q8TDY8|IGDCC4
     1  MARGDAGRGR GLLALTFCLL AARGELLLPQ ETTVELSCGV GPLQVILGPE QAAVLNCSLG
    61  AAAAGPPTRV TWSKDGDTLL EHDHLHLLPN GSLWLSQPLA PNGSDESVPE AVGVIEGNYS
   121  CLAHGPLGVL ASQTAVVKLA TLADFSLHPE SQTVEENGTA RFECHIEGLP APIITWEKDQ
   181  VTLPEEPRLI VLPNGVLQIL DVQESDAGPY RCVATNSARQ HFSQEALLSV AHRGSLASTR
   241  GQDVVIVAAP ENTTVVSGQS VVMECVASAD PTPFVSWVRQ DGKPISTDVI VLGRTNLLIA
   301  NAQPWHSGVY VCRANKPRTR DFATAAAELR VLAAPAITQA PEALSRTRAS TARFVCRASG
   361  EPRPALRWLH NGAPLRPNGR VKVQGGGGSL VITQIGLQDA GYYQCVAENS AGMACAAASL
   421  AVVVREGLPS APTRVTATPL SSSAVLVAWE RPEMHSEQII GFSLHYQKAR GMDNVEYQFA
   481  VNNDTTELQV RDLEPNTDYE FYVVAYSQLG ASRTSTPALV HTLDDVPSAA PQLSLSSPNP
   541  SDIRVAWLPL PPSLSNGQVV KYKIEYGLGK EDQIFSTEVR GNETQLMLNS LQPNKVYRVR
   601  ISAGTAAGFG APSQWMHHRT PSMHNQSHVP FAPAELKVQA KMESLVVSWQ PPPHPTQISG
   661  YKLYWREVGA EEEANGDRLP GGRGDQAWDV GPVRLKKKVK QYELTQLVPG RLYEVKLVAF
   721  NKHEDGYAAV WKGKTEKAPA PDMPIQRGPP LPPAHVHAES NSSTSIWLRW KKPDFTTVKI
   781  VNYTVRFSPW GLRNASLVTY YTSSGEDILI GGLKPFTKYE FAVQSHGVDM DGPFGSVVER
   841  STLPDRPSTP PSDLRLSPLT PSTVRLHWCP PTEPNGEIVE YLILYSSNHT QPEHQWTLLT
   901  TQGNIFSAEV HGLESDTRYF FKMGARTEVG PGPFSRLQDV ITLQEKLSDS LDMHSVTGII
   961  VGVCLGLLCL LACMCAGLRR SPHRESLPGL SSTATPGNPA LYSRARLGPP SPPAAHELES
  1021  LVHPHPQDWS PPPSDVEDRA EVHSLMGGGV SEGRSHSKRK ISWAQPSGLS WAGSWAGCEL
  1081  PQAGPRPALT RALLPPAGTG QTLLLQALVY DAIKGNGRKK SPPACRNQVE AEVIVHSDFS
  1141  ASNGNPDLHL QDLEPEDPLP PEAPDLISGV GDPGQGAAWL DRELGGCELA APGPDRLTCL
  1201  PEAASASCSY PDLQPGEVLE ETPGDSCQLK SPCPLGASPG LPRSPVSSSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGDCC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

tongue: 13 nTPM
skeletal muscle: 9.9 nTPM
ovary: 6.2 nTPM
placenta: 5.2 nTPM
epididymis: 4 nTPM
gallbladder: 3.9 nTPM

Single-cell type

epididymal principal cells: 105 nCPM
cone photoreceptor cells: 64 nCPM
leydig cells: 59 nCPM
gonadotrophs: 52 nCPM
adrenal cortex cells: 51 nCPM
myosatellite cells: 40 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 31 nTPM
medulla oblongata: 30 nTPM
midbrain: 27 nTPM
hypothalamus: 21 nTPM
spinal cord: 21 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 1.73
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGDCC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC39A10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGDCC4 as an antibody target. Whether an autoantibody or antibody against IGDCC4 could matter depends on whether native IGDCC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGDCC4 is annotated at the cell surface, where native IGDCC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGDCC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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