Seroatlas · Human Serome Atlas

SLC39A6

Zinc transporter ZIP6

Also known as: LIV-1, S39A6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13433
Gene
SLC39A6
Ensembl
ENSG00000141424
Chromosome
18
Canonical length
755 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>Q13433|SLC39A6
     1  MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL
    61  FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSEH
   121  EHHSDHDHHS HHNHAASGKN KRKALCPDHD SDSSGKDPRN SQGKGAHRPE HASGRRNVKD
   181  SVSASEVTST VYNTVSEGTH FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT
   241  NESVSEPRKG FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA
   301  RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSF
   361  LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR GPLFSHLSSQ NIEESAYFDS
   421  TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DDDVEIKKQL SKYESQLSTN
   481  EEKVDTDDRT EGYLRADSQE PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC
   541  HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI
   601  MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY
   661  NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS
   721  RWGYFFLQNA GMLLGFGIML LISIFEHKIV FRINF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • breast: 138 nTPM
  • prostate: 121 nTPM
  • seminal vesicle: 108 nTPM
  • parathyroid gland: 81 nTPM
  • fallopian tube: 60 nTPM
  • choroid plexus: 59 nTPM

Single-cell type

  • prostatic glandular cells: 586 nCPM
  • breast hormone-responsive cells: 534 nCPM
  • prostatic club cells: 181 nCPM
  • retinal pigment epithelial cells: 166 nCPM
  • melanocytes: 162 nCPM
  • urothelial cells: 123 nCPM

Immune cell

  • plasmacytoid DC: 34 nTPM
  • eosinophil: 31 nTPM
  • basophil: 29 nTPM
  • MAIT T-cell: 20 nTPM
  • intermediate monocyte: 20 nTPM
  • non-classical monocyte: 19 nTPM

Brain region

  • choroid plexus: 97 nTPM
  • midbrain: 65 nTPM
  • white matter: 63 nTPM
  • pons: 58 nTPM
  • hypothalamus: 54 nTPM
  • medulla oblongata: 53 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A6.

Disease | ImmuneIEDB

Conditions an epitope on SLC39A6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.13
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC39A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A6 as an antibody target. Whether an autoantibody or antibody against SLC39A6 could matter depends on whether native SLC39A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A6 is annotated at the cell surface, where native SLC39A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...