Seroatlas · Human Serome Atlas

SLC31A1

High affinity copper uptake protein 1

Also known as: COPT1, COPT1_HUMAN, CTR1, hCTR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15431
Gene
SLC31A1
Ensembl
ENSG00000136868
Chromosome
9
Canonical length
190 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>O15431|SLC31A1
     1  MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG
    61  LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH
   121  KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA
   181  VVVDITEHCH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC31A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • liver: 101 nTPM
  • salivary gland: 63 nTPM
  • duodenum: 42 nTPM
  • choroid plexus: 38 nTPM
  • small intestine: 35 nTPM
  • kidney: 27 nTPM

Single-cell type

  • adrenal medulla cells: 234 nCPM
  • prostatic glandular cells: 138 nCPM
  • hepatocytes: 125 nCPM
  • enterocytes: 121 nCPM
  • respiratory secretory cells: 120 nCPM
  • salivary acinar cells: 116 nCPM

Immune cell

  • non-classical monocyte: 31 nTPM
  • intermediate monocyte: 27 nTPM
  • classical monocyte: 21 nTPM
  • myeloid DC: 16 nTPM
  • neutrophil: 8.2 nTPM
  • total PBMC: 7.6 nTPM

Brain region

  • choroid plexus: 57 nTPM
  • pons: 27 nTPM
  • medulla oblongata: 17 nTPM
  • thalamus: 17 nTPM
  • spinal cord: 17 nTPM
  • midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC31A1.

Disease | AllUniProt

Conditions SLC31A1 is implicated in, by any mechanism.

  • Neurodegeneration and seizures due to copper transport defect (NSCT) MIM:620306

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 28 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodegeneration and seizures due to copper transport defect

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0.07
gnomAD missense Z
1.08
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC31A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC31A1 as an antibody target. Whether an autoantibody or antibody against SLC31A1 could matter depends on whether native SLC31A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC31A1 is annotated at the cell surface, where native SLC31A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC31A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC31A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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