Seroatlas · Human Serome Atlas

CERK

Ceramide kinase

Also known as: CERK1_HUMAN, dA59H18.2, dA59H18.3, DKFZp434E0211, FLJ21430, FLJ23239, hCERK, KIAA1646, LK4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCT0
Gene: CERK
Ensembl: ENSG00000100422
Chromosome: 22
Canonical length: 537 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>Q8TCT0|CERK
     1  MGATGAAEPL QSVLWVKQQR CAVSLEPARA LLRWWRSPGP GAGAPGADAC SVPVSEIIAV
    61  EETDVHGKHQ GSGKWQKMEK PYAFTVHCVK RARRHRWKWA QVTFWCPEEQ LCHLWLQTLR
   121  EMLEKLTSRP KHLLVFINPF GGKGQGKRIY ERKVAPLFTL ASITTDIIVT EHANQAKETL
   181  YEINIDKYDG IVCVGGDGMF SEVLHGLIGR TQRSAGVDQN HPRAVLVPSS LRIGIIPAGS
   241  TDCVCYSTVG TSDAETSALH IVVGDSLAMD VSSVHHNSTL LRYSVSLLGY GFYGDIIKDS
   301  EKKRWLGLAR YDFSGLKTFL SHHCYEGTVS FLPAQHTVGS PRDRKPCRAG CFVCRQSKQQ
   361  LEEEQKKALY GLEAAEDVEE WQVVCGKFLA INATNMSCAC RRSPRGLSPA AHLGDGSSDL
   421  ILIRKCSRFN FLRFLIRHTN QQDQFDFTFV EVYRVKKFQF TSKHMEDEDS DLKEGGKKRF
   481  GHICSSHPSC CCTVSNSSWN CDGEVLHSPA IEVRVHCQLV RLFARGIEEN PKPDSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CERK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 47 nTPM
cerebellum: 38 nTPM
heart muscle: 37 nTPM
thymus: 36 nTPM
duodenum: 30 nTPM
small intestine: 29 nTPM

Single-cell type

somatotrophs: 169 nCPM
lactotrophs: 144 nCPM
neutrophils: 122 nCPM
innate lymphoid cells: 110 nCPM
thyrotrophs: 106 nCPM
epicardial cells: 91 nCPM

Immune cell

MAIT T-cell: 18 nTPM
memory CD4 T-cell: 11 nTPM
T-reg: 10 nTPM
gdT-cell: 10 nTPM
memory CD8 T-cell: 10 nTPM
non-classical monocyte: 8.7 nTPM

Brain region

hypothalamus: 76 nTPM
midbrain: 71 nTPM
cerebellum: 66 nTPM
pons: 65 nTPM
medulla oblongata: 62 nTPM
thalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CERK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC31A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CERK as an antibody target. Whether an autoantibody or antibody against CERK could matter depends on whether native CERK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CERK is annotated at the cell surface, where native CERK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CERK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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