Seroatlas · Human Serome Atlas

SLC31A2

Protein SLC31A2

Also known as: COPT2, COPT2_HUMAN, CTR2, hCTR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15432
Gene: SLC31A2
Ensembl: ENSG00000136867
Chromosome: 9
Canonical length: 143 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nuclear speckles,Plasma membrane,Intermediate filaments

OverviewNCBI Gene

Enables copper ion transmembrane transporter activity. Involved in copper ion import. Located in late endosome membrane; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

143 residues, UniProt reviewed canonical sequence.

>O15432|SLC31A2
     1  MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL LNQVLVNLPT
    61  SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH VIQVVIGYFI MLAVMSYNTW
   121  IFLGVVLGSA VGYYLAYPLL STA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC31A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 536 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 536 nTPM
salivary gland: 386 nTPM
spinal cord: 115 nTPM
midbrain: 51 nTPM
adipose tissue: 45 nTPM
skin: 42 nTPM

Single-cell type

salivary acinar cells: 262 nCPM
kupffer cells: 204 nCPM
oligodendrocytes: 164 nCPM
lacrimal acinar cells: 143 nCPM
neutrophils: 122 nCPM
cytotrophoblasts: 120 nCPM

Immune cell

non-classical monocyte: 425 nTPM
neutrophil: 357 nTPM
intermediate monocyte: 332 nTPM
classical monocyte: 226 nTPM
myeloid DC: 135 nTPM
total PBMC: 105 nTPM

Brain region

white matter: 157 nTPM
medulla oblongata: 98 nTPM
basal ganglia: 87 nTPM
cerebellum: 80 nTPM
midbrain: 75 nTPM
pons: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

copper ion import
copper ion transport
intracellular copper ion homeostasis
regulation of copper ion transmembrane transport

Molecular functions

copper ion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC31A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC31A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC31A2 as an antibody target. Whether an autoantibody or antibody against SLC31A2 could matter depends on whether native SLC31A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC31A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC31A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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