C2orf72
Uncharacterized protein C2orf72
Also known as: CB072_HUMAN, LOC257407
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NCS6
- Gene
- C2orf72
- Ensembl
- ENSG00000204128
- Chromosome
- 2
- Canonical length
- 295 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
OverviewNCBI Gene
No narrative summary is available for C2orf72 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
295 residues, UniProt reviewed canonical sequence.
>A6NCS6|C2orf72
1 MERELEALAA RLARPAEPPF QALVEAAGGR GQVLLVGELW EREQSRALLR DFARAVFPPE
61 PGAAKPGGAA AEGAGPGAAR GAQRAARAAG AAGAAAAAAR AIRSPLVFVL CRASSLAARE
121 PRRRLREMLR DVRGRRRAGA ALVGVLVAEA GPEDAVAPGL RLLEALLRAV FGRQAGGPVQ
181 AAAYCPGLPA SCLAVQAAAC RALQAAGAGQ PVEGAWERPG LPGLLACFSW GPWSRRKNQD
241 VAACRSSAQE DFQEPEEELP LTAIFPNGDC DDLGRGSKAC DGVVHTPAEP TGDSRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C2orf72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- liver: 19 nTPM
- basal ganglia: 5.9 nTPM
- cerebral cortex: 5.2 nTPM
- amygdala: 4.9 nTPM
- hippocampal formation: 4.6 nTPM
- midbrain: 4.6 nTPM
Single-cell type
- astrocytes: 234 nCPM
- hepatocytes: 171 nCPM
- oligodendrocyte progenitor cells: 81 nCPM
- late spermatids: 67 nCPM
- bergmann glia: 66 nCPM
- cholangiocytes: 53 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- thalamus: 43 nTPM
- midbrain: 37 nTPM
- hippocampal formation: 29 nTPM
- cerebral cortex: 29 nTPM
- basal ganglia: 28 nTPM
- medulla oblongata: 26 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0.16
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- C2orf72-like, C-terminal
- Domain of unknown function (DUF4630)
InteractionsUniProt · HPA
Protein binding partners of C2orf72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C2orf72 as an antibody target. Whether an autoantibody or antibody against C2orf72 could matter depends on whether native C2orf72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C2orf72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C2orf72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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