Seroatlas · Human Serome Atlas

SLC15A4

Solute carrier family 15 member 4

Also known as: PHT1, PTR4, S15A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N697
Gene
SLC15A4
Ensembl
ENSG00000139370
Chromosome
12
Canonical length
577 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including L-histidine transmembrane transporter activity; peptide:proton symporter activity; and peptidoglycan transmembrane transporter activity. Involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of pattern recognition receptor signaling pathway. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q8N697|SLC15A4
     1  MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL
    61  FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF
   121  PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA
   181  DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF
   241  LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK
   301  MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT
   361  PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG
   421  ILESKRLNLV KEKTINQTIG NVVYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA
   481  PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA
   541  AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC15A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 36 nTPM
  • skeletal muscle: 27 nTPM
  • retina: 22 nTPM
  • bone marrow: 21 nTPM
  • blood vessel: 19 nTPM
  • tongue: 19 nTPM

Single-cell type

  • pdcs: 540 nCPM
  • neutrophils: 391 nCPM
  • müller glia: 262 nCPM
  • choroid plexus epithelial cells: 260 nCPM
  • late spermatids: 186 nCPM
  • late primary spermatocytes: 149 nCPM

Immune cell

  • plasmacytoid DC: 32 nTPM
  • neutrophil: 19 nTPM
  • gdT-cell: 7.3 nTPM
  • eosinophil: 7.2 nTPM
  • NK-cell: 6.9 nTPM
  • memory CD8 T-cell: 4.4 nTPM

Brain region

  • choroid plexus: 58 nTPM
  • white matter: 17 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 12 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
1.01
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC15A4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC15A4 as an antibody target. Whether an autoantibody or antibody against SLC15A4 could matter depends on whether native SLC15A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC15A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC15A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC15A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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