Seroatlas · Human Serome Atlas

TASL

TLR adapter interacting with SLC15A4 on the lysosome

Also known as: CXorf21, FLJ11577, TASL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAI6
Gene: TASL
Ensembl: ENSG00000120280
Chromosome: X
Canonical length: 301 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Involved in positive regulation of toll-like receptor 7 signaling pathway; positive regulation of toll-like receptor 8 signaling pathway; and regulation of lysosomal lumen pH. Located in cytosol; endolysosome membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q9HAI6|TASL
     1  MLSEGYLSGL EYWNDIHWSC ASYNEQVAGE KEEETNSVAT LSYSSVDETQ VRSLYVSCKS
    61  SGKFISSVHS RESQHSRSQR VTVLQTNPNP VFESPNLAAV EICRDASRET YLVPSSCKSI
   121  CKNYNDLQIA GGQVMAINSV TTDFPSESSF EYGPLLKSSE IPLPMEDSIS TQPSDFPQKP
   181  IQRYSSYWRI TSIKEKSSLQ MQNPISNAVL NEYLEQKVVE LYKQYIMDTV FHDSSPTQIL
   241  ASELIMTSVD QISLQVSREK NLETSKARDI VFSRLLQLMS TEITEISTPS LHISQYSNVN
   301  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TASL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
appendix: 10 nTPM
lymph node: 9.8 nTPM
tonsil: 9.6 nTPM
spleen: 9.2 nTPM
thymus: 5.4 nTPM

Single-cell type

monocyte progenitors: 149 nCPM
pdcs: 71 nCPM
cdc: 66 nCPM
plasma cells: 61 nCPM
neutrophils: 59 nCPM
monocytes: 48 nCPM

Immune cell

plasmacytoid DC: 46 nTPM
non-classical monocyte: 45 nTPM
neutrophil: 31 nTPM
myeloid DC: 25 nTPM
eosinophil: 24 nTPM
naive B-cell: 24 nTPM

Brain region

white matter: 4.8 nTPM
thalamus: 4.1 nTPM
pons: 3.5 nTPM
medulla oblongata: 3.4 nTPM
choroid plexus: 3.1 nTPM
spinal cord: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.84
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

TASL protein
TLR adaptor interacting with SLC15A4 on the lysosome

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TASL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TASL as an antibody target. Whether an autoantibody or antibody against TASL could matter depends on whether native TASL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TASL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TASL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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