Seroatlas · Human Serome Atlas

MIF4GD

MIF4G domain-containing protein

Also known as: AD023, MGC45027, MI4GD_HUMAN, MIFD, SLIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A9UHW6
Gene: MIF4GD
Ensembl: ENSG00000125457
Chromosome: 17
Canonical length: 222 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>A9UHW6|MIF4GD
     1  MGEPSREEYK IQSFDAETQQ LLKTALKDPG AVDLEKVANV IVDHSLQDCV FSKEAGRMCY
    61  AIIQAESKQA GQSVFRRGLL NRLQQEYQAR EQLRARSLQG WVCYVTFICN IFDYLRVNNM
   121  PMMALVNPVY DCLFRLAQPD SLSKEEEVDC LVLQLHRVGE QLEKMNGQRM DELFVLIRDG
   181  FLLPTGLSSL AQLLLLEIIE FRAAGWKTTP AAHKYYYSEV SD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIF4GD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 55 nTPM
bone marrow: 41 nTPM
blood vessel: 41 nTPM
lymph node: 31 nTPM
spleen: 28 nTPM
skin: 28 nTPM

Single-cell type

megakaryocytes: 136 nCPM
platelets: 130 nCPM
pdcs: 91 nCPM
esophageal apical cells: 83 nCPM
esophageal suprabasal cells: 72 nCPM
cdc: 56 nCPM

Immune cell

plasmacytoid DC: 227 nTPM
myeloid DC: 92 nTPM
classical monocyte: 78 nTPM
T-reg: 69 nTPM
total PBMC: 60 nTPM
MAIT T-cell: 57 nTPM

Brain region

white matter: 18 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 16 nTPM
spinal cord: 16 nTPM
midbrain: 15 nTPM
cerebellum: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIF4GD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIF4GD as an antibody target. Whether an autoantibody or antibody against MIF4GD could matter depends on whether native MIF4GD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIF4GD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIF4GD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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