Seroatlas · Human Serome Atlas

FEM1A

Protein fem-1 homolog A

Also known as: FEM1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSK4
Gene: FEM1A
Ensembl: ENSG00000141965
Chromosome: 19
Canonical length: 669 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q9BSK4|FEM1A
     1  MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL
    61  VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL
   121  RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS
   181  AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG
   241  QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA
   301  LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL
   361  EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ
   421  QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ
   481  LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH
   541  MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL
   601  IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE
   661  DLEAFIELH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FEM1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 256 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 256 nTPM
tongue: 113 nTPM
heart muscle: 17 nTPM
parathyroid gland: 9 nTPM
skin: 8.1 nTPM
pancreas: 8 nTPM

Single-cell type

thymic myoid cells: 131 nCPM
syncytiotrophoblasts: 34 nCPM
suprabasal keratinocytes: 30 nCPM
retinal pigment epithelial cells: 30 nCPM
cytotrophoblasts: 25 nCPM
esophageal suprabasal cells: 24 nCPM

Immune cell

basophil: 4.6 nTPM
intermediate monocyte: 3.2 nTPM
non-classical monocyte: 3 nTPM
classical monocyte: 2.8 nTPM
eosinophil: 2.8 nTPM
myeloid DC: 2.6 nTPM

Brain region

white matter: 21 nTPM
hippocampal formation: 20 nTPM
medulla oblongata: 20 nTPM
cerebellum: 20 nTPM
amygdala: 20 nTPM
cerebral cortex: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 1.42
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity
ubiquitin-like ligase-substrate adaptor activity
EP4 subtype prostaglandin E2 receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FEM1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FEM1A as an antibody target. Whether an autoantibody or antibody against FEM1A could matter depends on whether native FEM1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FEM1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FEM1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...