Seroatlas · Human Serome Atlas

SKOR1

SKI family transcriptional corepressor 1

Also known as: CORL1, FUSSEL15, LBXCOR1, SKOR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P84550
Gene: SKOR1
Ensembl: ENSG00000188779
Chromosome: 15
Canonical length: 965 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of BMP signaling pathway. Located in dendrite and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

965 residues, UniProt reviewed canonical sequence.

>P84550|SKOR1
     1  MALLCGLGQV TLRIWVSLPS QSENGIGFLA ARAFLRSGGM EALTTQLGPG REGSSSPNSK
    61  QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL AQISNTLLKN YSYNEIHNRR
   121  VALGITCVQC TPVQLEILRR AGAMPISSRR CGMITKREAE RLCKSFLGEH KPPKLPENFA
   181  FDVVHECAWG SRGSFIPARY NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA
   241  NFNSWRRHLK LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NGGSGGQGKG
   301  GAGGGGGGGP GCGAEMAPGP PPHKSLRCGE DEAAGPPGPP PPHPQRGLGL ATGASGPAGP
   361  GGPGGGAGVR SYPVIPVPSK GFGLLQKLPP PLFPHPYGFP TAFGLCPKKD DPVLGAGEPK
   421  GGPGTGSGGG GAGTGGGAGG PGASHLPPGA GAGPGGGAMF WGHQPSGAAK DAAAVAAAAA
   481  AATVYPTFPM FWPAAGSLPV PSYPAAQSQA KAVAAAVAAA AAAAAAAAGS GAPEPLDGAE
   541  PAKESGLGAE ERCPSALSRG PLDEDGTDEA LPPPLAPLPP PPPPPARKGS YVSAFRPVVK
   601  DTESIAKLYG SAREAYGAGP ARGPGPGAGS GGYVSPDFLS EGSSSYNSAS PDVDTADEPE
   661  VDVESNRFPD DEDAQEETEP SAPSAGGGPD GEQPTGPPSA TSSGADGPAN SPDGGSPRPR
   721  RRLGPPPAGR PAFGDLAAED LVRRPERSPP SGGGGYELRE PCGPLGGPAP AKVFAPERDE
   781  HVKSAAVALG PAASYVCTPE AHEPDKEDNH SPADDLETRK SYPDQRSISQ PSPANTDRGE
   841  DGLTLDVTGT HLVEKDIENL AREELQKLLL EQMELRKKLE REFQSLKDNF QDQMKRELAY
   901  REEMVQQLQI VRDTLCNELD QERKARYAIQ QKLKEAHDAL HHFSCKMLTP RHCTGNCSFK
   961  PPLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.3 nTPM
cerebral cortex: 1.1 nTPM
pituitary gland: 1.1 nTPM
spinal cord: 1.1 nTPM
testis: 1 nTPM
hypothalamus: 0.9 nTPM

Single-cell type

cone photoreceptor cells: 4.1 nCPM
late spermatids: 3.4 nCPM
gonadotrophs: 2.7 nCPM
retinal horizontal cells: 2 nCPM
thymic myoid cells: 1.4 nCPM
thyrotrophs: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 13 nTPM
medulla oblongata: 7 nTPM
spinal cord: 6.1 nTPM
pons: 5.2 nTPM
cerebral cortex: 4.2 nTPM
white matter: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 2.18
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKOR1 as an antibody target. Whether an autoantibody or antibody against SKOR1 could matter depends on whether native SKOR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKOR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SKOR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...