Seroatlas · Human Serome Atlas

KIAA0319L

Dyslexia-associated protein KIAA0319-like protein

Also known as: AAVR, K319L_HUMAN, KIAA1837

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZA0
Gene
KIAA0319L
Ensembl
ENSG00000142687
Chromosome
1
Canonical length
1049 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in neuron migration. Predicted to act upstream of or within several processes, including flagellated sperm motility; proacrosomal vesicle fusion; and receptor-mediated endocytosis of virus by host cell. Located in Golgi apparatus; cytoplasmic vesicle; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1049 residues, UniProt reviewed canonical sequence.

>Q8IZA0|KIAA0319L
     1  MEKRLGVKPN PASWILSGYY WQTSAKWLRS LYLFYTCFCF SVLWLSTDAS ESRCQQGKTQ
    61  FGVGLRSGGE NHLWLLEGTP SLQSCWAACC QDSACHVFWW LEGMCIQADC SRPQSCRAFR
   121  THSSNSMLVF LKKFQTADDL GFLPEDDVPH LLGLGWNWAS WRQSPPRAAL RPAVSSSDQQ
   181  SLIRKLQKRG SPSDVVTPIV TQHSKVNDSN ELGGLTTSGS AEVHKAITIS SPLTTDLTAE
   241  LSGGPKNVSV QPEISEGLAT TPSTQQVKSS EKTQIAVPQP VAPSYSYATP TPQASFQSTS
   301  APYPVIKELV VSAGESVQIT LPKNEVQLNA YVLQEPPKGE TYTYDWQLIT HPRDYSGEME
   361  GKHSQILKLS KLTPGLYEFK VIVEGQNAHG EGYVNVTVKP EPRKNRPPIA IVSPQFQEIS
   421  LPTTSTVIDG SQSTDDDKIV QYHWEELKGP LREEKISEDT AILKLSKLVP GNYTFSLTVV
   481  DSDGATNSTT ANLTVNKAVD YPPVANAGPN QVITLPQNSI TLFGNQSTDD HGITSYEWSL
   541  SPSSKGKVVE MQGVRTPTLQ LSAMQEGDYT YQLTVTDTIG QQATAQVTVI VQPENNKPPQ
   601  ADAGPDKELT LPVDSTTLDG SKSSDDQKII SYLWEKTQGP DGVQLENANS SVATVTGLQV
   661  GTYVFTLTVK DERNLQSQSS VNVIVKEEIN KPPIAKITGN VVITLPTSTA ELDGSKSSDD
   721  KGIVSYLWTR DEGSPAAGEV LNHSDHHPIL FLSNLVEGTY TFHLKVTDAK GESDTDRTTV
   781  EVKPDPRKNN LVEIILDINV SQLTERLKGM FIRQIGVLLG VLDSDIIVQK IQPYTEQSTK
   841  MVFFVQNEPP HQIFKGHEVA AMLKSELRKQ KADFLIFRAL EVNTVTCQLN CSDHGHCDSF
   901  TKRCICDPFW MENFIKVQLR DGDSNCEWSV LYVIIATFVI VVALGILSWT VICCCKRQKG
   961  KPKRKSKYKI LDATDQESLE LKPTSRAGIK QKGLLLSSSL MHSESELDSD DAIFTWPDRE
  1021  KGKLLHGQNG SVPNGQTPLK ARSPREEIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0319L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 33 nTPM
  • heart muscle: 33 nTPM
  • parathyroid gland: 32 nTPM
  • pancreas: 31 nTPM
  • tongue: 31 nTPM
  • liver: 28 nTPM

Single-cell type

  • cardiomyocytes: 299 nCPM
  • myonuclei: 267 nCPM
  • retinal bipolar cells: 242 nCPM
  • epicardial cells: 241 nCPM
  • neutrophils: 240 nCPM
  • adrenal cortex cells: 237 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • classical monocyte: 6.5 nTPM
  • eosinophil: 4.7 nTPM
  • NK-cell: 4.6 nTPM
  • basophil: 4 nTPM
  • myeloid DC: 3.6 nTPM

Brain region

  • thalamus: 41 nTPM
  • midbrain: 34 nTPM
  • amygdala: 32 nTPM
  • medulla oblongata: 30 nTPM
  • hypothalamus: 30 nTPM
  • cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0
gnomAD missense Z
1.56
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA0319L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0319L as an antibody target. Whether an autoantibody or antibody against KIAA0319L could matter depends on whether native KIAA0319L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0319L is annotated at the cell surface, where native KIAA0319L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIAA0319L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA0319L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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