Seroatlas · Human Serome Atlas

UGCG

Ceramide glucosyltransferase

Also known as: CEGT_HUMAN, GCS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16739
Gene
UGCG
Ensembl
ENSG00000148154
Chromosome
9
Canonical length
394 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q16739|UGCG
     1  MALLDLALEG MAVFGFVLFL VLWLMHFMAI IYTRLHLNKK ATDKQPYSKL PGVSLLKPLK
    61  GVDPNLINNL ETFFELDYPK YEVLLCVQDH DDPAIDVCKK LLGKYPNVDA RLFIGGKKVG
   121  INPKINNLMP GYEVAKYDLI WICDSGIRVI PDTLTDMVNQ MTEKVGLVHG LPYVADRQGF
   181  AATLEQVYFG TSHPRYYISA NVTGFKCVTG MSCLMRKDVL DQAGGLIAFA QYIAEDYFMA
   241  KAIADRGWRF AMSTQVAMQN SGSYSISQFQ SRMIRWTKLR INMLPATIIC EPISECFVAS
   301  LIIGWAAHHV FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG TLCFSKLDYA VAWFIRESMT
   361  IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGCG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 107 nTPM
  • urinary bladder: 68 nTPM
  • adrenal gland: 62 nTPM
  • stomach: 45 nTPM
  • tonsil: 44 nTPM
  • gallbladder: 40 nTPM

Single-cell type

  • neutrophil progenitors: 1,447 nCPM
  • esophageal apical cells: 1,019 nCPM
  • pdcs: 984 nCPM
  • endometrial glandular cells: 790 nCPM
  • urothelial cells: 635 nCPM
  • neutrophils: 424 nCPM

Immune cell

  • plasmacytoid DC: 110 nTPM
  • naive B-cell: 5.3 nTPM
  • memory B-cell: 4.2 nTPM
  • T-reg: 3.6 nTPM
  • memory CD4 T-cell: 2.2 nTPM
  • MAIT T-cell: 2 nTPM

Brain region

  • hypothalamus: 25 nTPM
  • white matter: 25 nTPM
  • midbrain: 24 nTPM
  • thalamus: 22 nTPM
  • medulla oblongata: 21 nTPM
  • cerebellum: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.94
gnomAD missense Z
2.74
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • ceramide glucosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UGCG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGCG as an antibody target. Whether an autoantibody or antibody against UGCG could matter depends on whether native UGCG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGCG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGCG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UGCG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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