Seroatlas · Human Serome Atlas

RSPH6A

Radial spoke head protein 6 homolog A

Also known as: RSH6A_HUMAN, RSHL1, RSP4, RSP6, RSPH4B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0K4
Gene: RSPH6A
Ensembl: ENSG00000104941
Chromosome: 19
Canonical length: 717 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is similar to a sea urchin radial spoke head protein. Radial spoke protein complexes form part of the axoneme of eukaryotic flagella and are located between the axoneme's outer ring of doublet microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns. This gene maps to a region of chromosome 19 that is linked to primary ciliary dyskinesia-2 (CILD2). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

717 residues, UniProt reviewed canonical sequence.

>Q9H0K4|RSPH6A
     1  MGDLPPYPER PAQQPPGRRT SQASQRRHSR DQAQALAADP EERQQIPPDA QRNAPGWSQR
    61  GSLSQQENLL MPQVFQAEEA RLGGMEYPSV NTGFPSEFQP QPYSDESRMQ VAELTTSLML
   121  QRLQQGQSSL FQQLDPTFQE PPVNPLGQFN LYQTDQFSEG AQHGPYIRDD PALQFLPSEL
   181  GFPHYSAQVP EPEPLELAVQ NAKAYLLQTS INCDLSLYEH LVNLLTKILN QRPEDPLSVL
   241  ESLNRTTQWE WFHPKLDTLR DDPEMQPTYK MAEKQKALFT RSGGGTEGEQ EMEEEVGETP
   301  VPNIMETAFY FEQAGVGLSS DESFRIFLAM KQLVEQQPIH TCRFWGKILG IKRSYLVAEV
   361  EFREGEEEAE EEEVEEMTEG GEVMEAHGEE EGEEDEEKAV DIVPKSVWKP PPVIPKEESR
   421  SGANKYLYFV CNEPGLPWTR LPHVTPAQIV NARKIKKFFT GYLDTPVVSY PPFPGNEANY
   481  LRAQIARISA ATQVSPLGFY QFSEEEGDEE EEGGAGRDSY EENPDFEGIP VLELVDSMAN
   541  WVHHTQHILP QGRCTWVNPL QKTEEEEDLG EEEEKADEGP EEVEQEVGPP LLTPLSEDAE
   601  IMHLAPWTTR LSCSLCPQYS VAVVRSNLWP GAYAYASGKK FENIYIGWGH KYSPESFNPA
   661  LPAPIQQEYP SGPEIMEMSD PTVEEEQALK AAQEQALGAT EEEEEGEEEE EGEETDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPH6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
thyroid gland: 2.6 nTPM
epididymis: 0.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 157 nCPM
early spermatids: 79 nCPM
breast lactating cells: 18 nCPM
late spermatids: 13 nCPM
retinal ganglion cells: 7.7 nCPM
hepatic stellate cells: 6.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.7 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.6 nTPM
white matter: 0.6 nTPM
amygdala: 0.5 nTPM
cerebellum: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPH6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPH6A as an antibody target. Whether an autoantibody or antibody against RSPH6A could matter depends on whether native RSPH6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPH6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSPH6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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