Seroatlas · Human Serome Atlas

LRRC23

Leucine-rich repeat-containing protein 23

Also known as: B7, LRC23_HUMAN, LRPB7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53EV4
Gene
LRRC23
Ensembl
ENSG00000010626
Chromosome
12
Canonical length
343 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Nucleoli rim

OverviewNCBI Gene

Involved in flagellated sperm motility and radial spoke assembly. Located in cytoplasm and sperm flagellum. Implicated in spermatogenic failure 92. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q53EV4|LRRC23
     1  MSDEDDLEDS EPDQDDSEKE EDEKETEEGE DYRKEGEEFP EEWLPTPLTE DMMKEGLSLL
    61  CKTGNGLAHA YVKLEVKERD LTDIYLLRSY IHLRYVDISE NHLTDLSPLN YLTHLLWLKA
   121  DGNRLRSAQM NELPYLQIAS FAYNQITDTE GISHPRLETL NLKGNSIHMV TGLDPEKLIS
   181  LHTVELRGNQ LESTLGINLP KLKNLYLAQN MLKKVEGLED LSNLTTLHLR DNQIDTLSGF
   241  SREMKSLQYL NLRGNMVANL GELAKLRDLP KLRALVLLDN PCTDETSYRQ EALVQMPYLE
   301  RLDKEFYEEE ERAEADVIRQ RLKEEKEQEP EPQRDLEPEQ SLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 96 nTPM
  • choroid plexus: 32 nTPM
  • testis: 24 nTPM
  • retina: 23 nTPM
  • epididymis: 12 nTPM
  • basal ganglia: 12 nTPM

Single-cell type

  • respiratory ciliated cells: 338 nCPM
  • fallopian tube ciliated cells: 298 nCPM
  • endometrial ciliated cells: 239 nCPM
  • epididymal efferent duct ciliated cells: 222 nCPM
  • ependymal cells: 177 nCPM
  • epididymal basal cells: 148 nCPM

Immune cell

  • eosinophil: 6.4 nTPM
  • memory B-cell: 5.8 nTPM
  • NK-cell: 4 nTPM
  • plasmacytoid DC: 3.9 nTPM
  • MAIT T-cell: 3 nTPM
  • naive B-cell: 2.8 nTPM

Brain region

  • midbrain: 34 nTPM
  • choroid plexus: 29 nTPM
  • medulla oblongata: 26 nTPM
  • spinal cord: 21 nTPM
  • pons: 14 nTPM
  • white matter: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC23.

Disease | AllUniProt

Conditions LRRC23 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 61 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 92

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.25
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC23 as an antibody target. Whether an autoantibody or antibody against LRRC23 could matter depends on whether native LRRC23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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