Seroatlas · Human Serome Atlas

RSBN1

Lysine-specific demethylase 9

Also known as: FLJ11220, ROSBIN, RSBN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWQ0
Gene: RSBN1
Ensembl: ENSG00000081019
Chromosome: 1
Canonical length: 802 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable histone H4K20 demethylase activity and metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>Q5VWQ0|RSBN1
     1  MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA AQVGAVRVVR
    61  AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR GRPSQEPPLA PPHRRRRSRQ
   121  HPGPLPPTNA APTVPGPVEP LLLPPPPPPS LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA
   181  AGPKHKGHKE RHKHHHHRGP DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN
   241  GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
   301  TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL KTGTKFSNFI
   361  HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
   421  YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
   481  GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP
   541  TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
   601  LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
   661  EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVEA TQNTESNSNM
   721  DCGLTGKREL EVDSQCVRIK TESEEACTEI QLLTTASSSF PPASELNLQQ DQKTQPIPVL
   781  KVESRLDSDQ QHNLQEHSTT SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSBN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
retina: 12 nTPM
thymus: 11 nTPM
cerebellum: 10 nTPM
ovary: 10 nTPM
pancreas: 9.5 nTPM

Single-cell type

neutrophils: 286 nCPM
neutrophil progenitors: 210 nCPM
t-cells: 133 nCPM
innate lymphoid cells: 127 nCPM
lactotrophs: 104 nCPM
megakaryocyte-erythroid progenitors: 98 nCPM

Immune cell

basophil: 51 nTPM
naive B-cell: 33 nTPM
memory B-cell: 32 nTPM
naive CD4 T-cell: 32 nTPM
memory CD4 T-cell: 31 nTPM
T-reg: 30 nTPM

Brain region

cerebellum: 34 nTPM
hypothalamus: 19 nTPM
white matter: 19 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.1
gnomAD missense Z: 2.11
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spermatogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RSBN1/Dpy-21/CEP530

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSBN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSBN1 as an antibody target. Whether an autoantibody or antibody against RSBN1 could matter depends on whether native RSBN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSBN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSBN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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