Seroatlas · Human Serome Atlas

RSBN1L

Lysine-specific demethylase RSBN1L

Also known as: FLJ42526, FLJ45813, MGC71764, RSBNL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PCB5
Gene: RSBN1L
Ensembl: ENSG00000187257
Chromosome: 7
Canonical length: 846 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

Predicted to enable dioxygenase activity and metal ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

846 residues, UniProt reviewed canonical sequence.

>Q6PCB5|RSBN1L
     1  MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK KAPRRVNGEG
    61  GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS RSSFSFSAGT AVPSSASASL
   121  SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA ASANAKSRRP KEKREKERRR HGLGGAREAG
   181  GASREENGEV KPLPRDKIKD KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP
   241  KTNIEDLQIK KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI
   301  KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH IEHQPNGGAS
   361  VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV MGIVHGAATY LPDFLDYFSF
   421  NFPNSPVKME ILGKKDIETT TMSNFHAQVK RTYSHGTYRA GPMRQISLVG AVDEEVGDYF
   481  PEFLDMLEES PFLKCTLPWG TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR
   541  KRTTNEIKNL QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD
   601  QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE GIRYARIQLY
   661  DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS QNTATHETGT SSDSTSSVLG
   721  PHTDNMICAV SKASLDSVFS DKLHSKYELQ QIKHEPIASV RIKEEPVNVN IPEKTTALNN
   781  MDGKNVKAKL DHVQFAEFKI DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK
   841  DDDILC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSBN1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

retina: 28 nTPM
testis: 25 nTPM
thymus: 17 nTPM
thyroid gland: 16 nTPM
lymph node: 15 nTPM
spleen: 14 nTPM

Single-cell type

neutrophils: 399 nCPM
early spermatids: 339 nCPM
rod photoreceptor cells: 310 nCPM
retinal bipolar cells: 231 nCPM
cone photoreceptor cells: 230 nCPM
neutrophil progenitors: 206 nCPM

Immune cell

neutrophil: 55 nTPM
basophil: 18 nTPM
plasmacytoid DC: 13 nTPM
naive B-cell: 12 nTPM
eosinophil: 11 nTPM
memory B-cell: 9.8 nTPM

Brain region

cerebellum: 41 nTPM
white matter: 26 nTPM
hypothalamus: 23 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 22 nTPM
spinal cord: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.8
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

RSBN1/Dpy-21/CEP530

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSBN1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSBN1L as an antibody target. Whether an autoantibody or antibody against RSBN1L could matter depends on whether native RSBN1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSBN1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSBN1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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