Seroatlas · Human Serome Atlas

RRP8

Ribosomal RNA-processing protein 8

Also known as: KIAA0409, NML, RRP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43159
Gene: RRP8
Ensembl: ENSG00000132275
Chromosome: 11
Canonical length: 456 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Acts upstream of with a negative effect on regulation of G1 to G0 transition. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of eNoSc complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>O43159|RRP8
     1  MFEEPEWAEA APVAAGLGPV ISRPPPAASS QNKGSKRRQL LATLRALEAA SLSQHPPSLC
    61  ISDSEEEEEE RKKKCPKKAS FASASAEVGK KGKKKCQKQG PPCSDSEEEV ERKKKCHKQA
   121  LVGSDSAEDE KRKRKCQKHA PINSAQHLDN VDQTGPKAWK GSTTNDPPKQ SPGSTSPKPP
   181  HTLSRKQWRN RQKNKRRCKN KFQPPQVPDQ APAEAPTEKT EVSPVPRTDS HEARAGALRA
   241  RMAQRLDGAR FRYLNEQLYS GPSSAAQRLF QEDPEAFLLY HRGFQSQVKK WPLQPVDRIA
   301  RDLRQRPASL VVADFGCGDC RLASSIRNPV HCFDLASLDP RVTVCDMAQV PLEDESVDVA
   361  VFCLSLMGTN IRDFLEEANR VLKPGGLLKV AEVSSRFEDV RTFLRAVTKL GFKIVSKDLT
   421  NSHFFLFDFQ KTGPPLVGPK AQLSGLQLQP CLYKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

colon: 21 nTPM
liver: 21 nTPM
bone marrow: 17 nTPM
urinary bladder: 16 nTPM
prostate: 15 nTPM
heart muscle: 15 nTPM

Single-cell type

esophageal basal cells: 32 nCPM
megakaryocyte progenitors: 30 nCPM
migrating cytotrophoblasts: 30 nCPM
erythrocyte progenitors: 29 nCPM
cytotrophoblasts: 28 nCPM
esophageal suprabasal cells: 28 nCPM

Immune cell

basophil: 26 nTPM
NK-cell: 14 nTPM
myeloid DC: 13 nTPM
T-reg: 12 nTPM
naive B-cell: 12 nTPM
non-classical monocyte: 12 nTPM

Brain region

white matter: 14 nTPM
spinal cord: 12 nTPM
amygdala: 12 nTPM
cerebral cortex: 12 nTPM
thalamus: 11 nTPM
midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRP8.

Disease | ImmuneIEDB

Conditions an epitope on RRP8 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -1.18
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

UbiE/COQ5 methyltransferase, conserved site
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Ribosomal RNA processing protein 8
Ribosomal RNA-processing protein 8, N-terminal domain
Hypothetical methyltransferase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRP8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP8 as an antibody target. Whether an autoantibody or antibody against RRP8 could matter depends on whether native RRP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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