Seroatlas · Human Serome Atlas

RAMACL

RNA guanine-N7 methyltransferase-activating subunit-like protein

Also known as: RMACL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A3B3IU46
Gene
RAMACL
Canonical length
118 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RAMACL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>A0A3B3IU46|RAMACL
     1  MTDTAEAVPN FEEMFASRFT ENDKEYQEYL KRPPESPPIV EEWNSRAGGN QRNRGNRLQD
    61  NRQFRGRDNR WGWPSDNRSN QWHGRSWGNN YPQHRQEPYY PQQYGHYGYN QRPPYGYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAMACL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0.9 nTPM
  • skin: 0.8 nTPM
  • breast: 0.6 nTPM
  • lung: 0.6 nTPM
  • skeletal muscle: 0.6 nTPM
  • vagina: 0.6 nTPM

Single-cell type

  • late spermatids: 0.6 nCPM
  • foveolar cells: 0.4 nCPM
  • enterocytes: 0.1 nCPM
  • epididymal efferent duct absorptive cells: 0.1 nCPM
  • pancreatic acinar cells: 0.1 nCPM
  • adipocytes: 0 nCPM

Immune cell

  • neutrophil: 1.6 nTPM
  • eosinophil: 1.3 nTPM
  • memory B-cell: 1 nTPM
  • naive B-cell: 1 nTPM
  • myeloid DC: 0.9 nTPM
  • NK-cell: 0.9 nTPM

Brain region

  • white matter: 9.6 nTPM
  • medulla oblongata: 7.3 nTPM
  • hypothalamus: 6.3 nTPM
  • pons: 6.3 nTPM
  • amygdala: 6.1 nTPM
  • thalamus: 5.9 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAMACL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAMACL as an antibody target. Whether an autoantibody or antibody against RAMACL could matter depends on whether native RAMACL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAMACL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAMACL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAMACL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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