Seroatlas · Human Serome Atlas

RNGTT

mRNA-capping enzyme

Also known as: hCAP, HCE, HCE1, MCE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60942
Gene: RNGTT
Ensembl: ENSG00000111880
Chromosome: 6
Canonical length: 597 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>O60942|RNGTT
     1  MAHNKIPPRW LNCPRRGQPV AGRFLPLKTM LGPRYDSQVA EENRFHPSML SNYLKSLKVK
    61  MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT ENTETFIRLC ERFNERNPPE
   121  LIGVHCTHGF NRTGFLICAF LVEKMDWSIE AAVATFAQAR PPGIYKGDYL KELFRRYGDI
   181  EEAPPPPLLP DWCFEDDEDE DEDEDGKKES EPGSSASFGK RRKERLKLGA IFLEGVTVKG
   241  VTQVTTQPKL GEVQQKCHQF CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY
   301  MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL
   361  IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEPFSV RNKPFFDICT
   421  SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP GRCDDILKWK PPSLNSVDFR LKITRMGGEG
   481  LLPQNVGLLY VGGYERPFAQ IKVTKELKQY DNKIIECKFE NNSWVFMRQR TDKSFPNAYN
   541  TAMAVCNSIS NPVTKEMLFE FIDRCTAASQ GQKRKHHLDP DTELMPPPPP KRPRPLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNGTT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

tonsil: 16 nTPM
lymph node: 16 nTPM
thymus: 14 nTPM
retina: 9.8 nTPM
bone marrow: 9 nTPM
testis: 8.7 nTPM

Single-cell type

neutrophil progenitors: 425 nCPM
ependymal cells: 337 nCPM
monocyte progenitors: 258 nCPM
rod photoreceptor cells: 222 nCPM
b-cells: 219 nCPM
pituicytes/fscs: 217 nCPM

Immune cell

memory B-cell: 23 nTPM
naive B-cell: 23 nTPM
NK-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM
memory CD8 T-cell: 9.7 nTPM
naive CD4 T-cell: 9.7 nTPM

Brain region

cerebellum: 21 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 13 nTPM
midbrain: 12 nTPM
pons: 12 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.37
gnomAD missense Z: 3
DepMap mean gene effect: -1.86
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
GTP binding
phosphoprotein phosphatase activity
polynucleotide 5'-phosphatase activity
inorganic triphosphate phosphatase activity
mRNA 5'-triphosphate monophosphatase activity
mRNA guanylyltransferase activity
RNA guanylyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dual specificity phosphatase, catalytic domain
Tyrosine-specific protein phosphatases domain
Nucleic acid-binding, OB-fold
Protein-tyrosine phosphatase, active site
Dual specificity protein phosphatase domain
Protein-tyrosine phosphatase-like
Dual specificity phosphatase, catalytic domain
mRNA capping enzyme, adenylation domain
mRNA capping enzyme, C-terminal domain
mRNA capping enzyme, bifunctional
mRNA capping enzyme, catalytic domain
mRNA capping enzyme, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNGTT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNGTT as an antibody target. Whether an autoantibody or antibody against RNGTT could matter depends on whether native RNGTT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNGTT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNGTT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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