Seroatlas · Human Serome Atlas

DRGX

Dorsal root ganglia homeobox protein

Also known as: DRG11, DRGX_HUMAN, PRRXL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNA5
Gene: DRGX
Ensembl: ENSG00000165606
Chromosome: 10
Canonical length: 263 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>A6NNA5|DRGX
     1  MFYFHCPPQL EGTATFGNHS SGDFDDGFLR RKQRRNRTTF TLQQLEALEA VFAQTHYPDV
    61  FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP GAKEPMAEVT PPPVRNINSP
   121  PPGDQARSKK EALEAQQSLG RTVGPAGPFF PSCLPGTLLN TATYAQALSH VASLKGGPLC
   181  SCCVPDPMGL SFLPTYGCQS NRTASVATLR MKAREHSEAV LQSANLLPST SSSPGPVAKP
   241  APPDGSQEKT SPTKEQSEAE KSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRGX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 5.1 nTPM
spinal cord: 1.9 nTPM
cerebral cortex: 1.2 nTPM
midbrain: 0.4 nTPM
skin: 0.4 nTPM
pituitary gland: 0.2 nTPM

Single-cell type

adrenal medulla cells: 43 nCPM
late spermatids: 2.3 nCPM
early spermatids: 1.2 nCPM
ependymal cells: 1 nCPM
alveolar cells type 2: 0.9 nCPM
cdc: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 22 nTPM
spinal cord: 17 nTPM
medulla oblongata: 9.3 nTPM
white matter: 1.7 nTPM
midbrain: 1.6 nTPM
cerebral cortex: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRGX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RGMB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRGX as an antibody target. Whether an autoantibody or antibody against DRGX could matter depends on whether native DRGX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRGX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRGX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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