STK39

Protein identityUniProt · HPA

UniProt accession

Q9UEW8

Gene

STK39

Ensembl

ENSG00000198648

Chromosome

2

Canonical length

545 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q9UEW8|STK39
     1  MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR
    61  DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN
   121  VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL
   181  DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA
   241  PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK
   301  EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR
   361  AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS
   421  TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD
   481  GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA
   541  QLSVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

65 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

2.11

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell volume homeostasis
• cellular hyperosmotic response
• cellular hypotonic response
• cellular response to chemokine
• cellular response to potassium ion
• chemokine (C-X-C motif) ligand 12 signaling pathway
• inflammatory response
• intracellular chloride ion homeostasis
• intracellular signal transduction
• macrophage activation
• maintenance of lens transparency
• negative regulation of pancreatic juice secretion
• negative regulation of potassium ion transmembrane transport
• negative regulation of sodium ion transmembrane transport
• negative regulation of transmembrane transport
• peptidyl-serine phosphorylation
• peptidyl-threonine phosphorylation
• positive regulation of p38MAPK cascade
• positive regulation of potassium ion import across plasma membrane
• positive regulation of T cell chemotaxis
• protein autophosphorylation
• protein phosphorylation
• regulation of blood pressure
• regulation of inflammatory response
• regulation of monoatomic cation transmembrane transport
• renal sodium ion absorption
• response to aldosterone
• response to dietary excess
• signal transduction
• sodium ion transmembrane transport
• positive regulation of sodium ion import across plasma membrane

Molecular functions

• ATP binding
• ion channel regulator activity
• kinase activity
• potassium channel inhibitor activity
• protein kinase binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• transmembrane transporter binding
• transporter activator activity
• transporter inhibitor activity

Cellular components

• apical plasma membrane
• basolateral plasma membrane
• cell body
• cell cortex
• cytoplasm
• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Serine/threonine-protein kinase OSR1/WNK, CCT domain
• STE20/SPS1-related Proline-Alanine-rich Kinase
• Protein kinase domain
• Oxidative-stress-responsive kinase 1 C-terminal domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of STK39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SORL1
• RELT
• SLC12A6